Inducerede pluripotente stamceller til behandling af Parkinsons sygdom

Mads Teglhus Henriksen, Helen Halskov Lambert, Zilas Kjær Mikkelsen, Nadia Ahrensborg Bülow Sleiman & Rasmus Tronier Hansen

Studenteropgave: Semesterprojekt

Abstrakt

Parkinson’s disease is one of the most common neurodegenerative diseases. The disease is known to affect approximately 1 out of 500 people worldwide. Scientists across the world have tried attempted to discover a cure without success. Levodopa was the first effective treatment option for patients with Parkinson’s disease, but the lack of consistency made the drug ineffective over time. Therefore, scientists searched for a new treatment and they discovered embryonic stem cells (ESC). Unfortunately, the ethical concerns caused scientist to search for an even better solution. Based on the research found in the field of embryonic stem cells, Takahashi & Yamanaka 20061 discovered induced pluripotent stem cells (iPSc). With iPSc many of the ethical issues are not present due to the fact that iPSc is produced from human somatic cells. Stem cells and also their efficiency in cell therapy for patients suffering from PS are the main focus of this paper. We will disclose the process from which a human somatic cell is reprogrammed into an iPSc, from iPSc to dopamine producing neurons and how far along scientists are in the attempt of finding a cure. As insight for this topic, we used scientific papers,books and articles. Based on the knowledge and information from these sources did we conclude that: iPSc is capable of increasing the dopamine producing neurons that causes Parkinson’s disease and will therefore have the potential to enhance life quality of individuals suffering from Parkinson’s disease.

UddannelserBasis - Naturvidenskabelig Bacheloruddannelse, (Bachelor uddannelse) Basis
SprogDansk
Udgivelsesdato21 jan. 2016
VejledereJohanne Davidsen

Emneord

  • Parkinsons sygdom
  • Inducerede pluripotente stamceller