How to Treat Bacterial Biofilm Infection on Medical Implants?

Andreas Kaas-Mason, Wessam Al Mardoud, Vit Zemanek, Irida Gkouzou, Christina Sigala, Mathis Brette Mortensen & Natalia Stati

Studenteropgave: Basisprojekt

Abstrakt

Biofilms are a group of microbial cells which attach to an exopolysaccharide matrix (an
environment created by the secretion of microorganisms) on the surface of a medical implant.
These biofilms which form on medical implants lead to infections and are a serious threat to public
health and negatively affect the function of the implant. Biofilm formation on medical implants is
of growing concern to researchers because biofilms cannot be efficiently treated by common
antibiotic therapy. This issue is further complicated by the occurrence of antibiotic resistant
bacteria (superbugs). This report examines what novel methods of treatment are suitable for
treatment and prevention of biofilm growth on medical implants. The report focuses on active
release coatings and anti-adhesive coatings. Both strategies involve coating the surface of the
implants either actively(active release) or passively(anti-adhesive). The strategies are identified,
compared, and their strengths and weaknesses as well as the current stage of research on this topic
are discussed. The main criteria for the comparison are: phase of research, biological suitability of
used materials or procedures, observed benefits and known limitations. After researching new
methods and strategies of treatment, it is clear that most of them are still under research in an
experimental stage with encouraging results, while others are commercially used. Despite this,
there is no perfect, single solution that could prevent or treat biofilm infections on medical
implants in human bodies. Also, the experiment simulating conditions inside a human body was
conducted in order to illustrate the biofilm growth of Pseudomonas aeruginosa on the surface of
contact lenses.

UddannelserBasis - International Naturvidenskabelig Bacheloruddannelse, (Bachelor uddannelse) Bachelor
SprogEngelsk
Udgivelsesdato19 dec. 2017
Antal sider58
VejledereAthina Andrea