How significant is the interaction between the complex of pesticin immune polypeptide (Pim) and pesticin as a virulence effector on bacteria from the same niche?

Mike Elean Castillo Alonso, Laura Daniela Martinenghi, Klaudia Daria Powroznik & Sandra Bulatovic

Studenteropgave: Fagmodulprojekt

Abstrakt

For decades, the main focus has been to investigate how to approach the antibiotic resistance in bacterial pathogens, in order to establish alternative therapeutic strategies to prevent a possible outbreak of an epidemy. In order to find a broader scope for microbial treatments, bacteriocins have increased interest among researchers. Yersinia pestis is a Gram-negative bacterium, that produces pesticin, an antimicrobial peptide responsible for killing closely related species such as Yersinia pestis, Yersinia enterocolitica, Yersinia pseudotuberculosis and some Escherichia coli strains. For the survival of the species, Y. pestis bacteria encode an antagonist immune protein Pim. Pim and Pst interact in the periplasmic space, though the translocation of the proteins along with the recognition from the receptor, play a critical role for facilitating this interaction, thus the inhibition of the viral effect of pesticin. Avoiding the neutralizing response of immune protein Pim, disrupting the contact with Pst has been the mainly documented through this paper. The significance of interrupting this synergy between pesticin and its immune protein lead to a promising new approach to microbial therapy.

UddannelserMolekylærbiologi, (Bachelor/kandidatuddannelse) Bachelor
SprogEngelsk
Udgivelsesdato28 maj 2018
Antal sider24
VejledereKornelius Zeth

Emneord

  • pesticide
  • pim
  • pst
  • bacteriocin
  • resistance
  • antibiotic
  • therapy
  • phage