Globale ændringer i proteinsyntese i tarmepitelet hos patienter med Inflammatory Bowel Disease

Heidi Hvid Nielsen, Anders Birchvald Jensen & Julie Heiden Nielsen

Studenteropgave: Semesterprojekt

Abstrakt

Inflammatory bowel disease (IBD) is a group of chronic inflammatory intestinal diseases. Caudal-related homeobox transcription factor 2 (CDX2) is a transcription factor in the intestinal epithelium, shown suppressed at IBD. CDX2 is necessary for differentiation of intestinal epithelium cells. A variant of CDX2 is found expressed from an alternative promotor in IBD patients. This variant is assumed translational initiated at CUG. CUG as start codon is normally enhanced for cells under endoplasmic reticulum stress (ER stress). An assumption for the progress of IBD, during ER stress is suppression of AUG as start codon, and enhanced use of CUG as a start codon. This review examines if there is found correlation between IBD and ER stress, and if ER stress can cause enhanced translation initiation from CUG. ER stress activates the unfolded protein response (UPR), which includes phosphorylation of eIF2α. Phosphorylation of eIF2α suppresses translation initiation from AUG, and is not seen to have influence on the use of CUG as start codon. Translation initiation from CUG occurs naturally and without ER stress. The conclusion of this review is, that by IBD is found evidence of ER stress, and a consequence of this is a more frequent translation initiation from non-AUG start codons.

UddannelserMolekylærbiologi, (Bachelor/kandidatuddannelse) Bachelor el. kandidat
SprogDansk
Udgivelsesdato1 jun. 2014

Emneord

  • Endoplamatisk Reticulum
  • Translation
  • Start Codon
  • Inflammatory Bowel Disease