This project aims to investigate the effect of Disulfiram (DSF) on Ubiquitin Protein system of cancer cells. The rapport gives an insight into the molecular mechanisms of cancer, mainly Glioblastoma and investigate how Disulfiram effect the ubiquitin proteosome system of tumor cells. The ubiquitin proteosome is essential for degradation of most of the cellular proteins, and thereby plays a major role in in protein homeostasis. In recent years Disulfiram has appeared to target cancer cells and reduced tumor progression by inhibiting the ubiquitin proteosom system and initiating apoptosis. It is important to highlight that the tumor cytotoxic activity of DSF is copper-dependent and enhanced by the precence of copper. Furthermore, studies have identified NPL4(p97/segragase) essential for protein turnover as the molecular target for Disulfiram.
Due to these discoveries there is a huge interest in repurposing Disulfiram (DSF) for cancer treatment to reduce the morbidity and mortality for cancer patients.
|Uddannelser||Medicinalbiologi, (Bachelor/kandidatuddannelse) Bachelor|
|Udgivelsesdato||26 maj 2019|
|Vejledere||Peter Michael Vestlev|