Attempts to Synthesize 3-acyl-4-hydroxycoumarins from Meldrum’s acid -- and Related Chemistry

Fengbin Ye, Kristin Tropp & Yiting Yu

Studenteropgave: Semesterprojekt


We start our synthetic work with the acylation of Meldrum’s acid to get three different 5-acyl Meldrum’s acids. These compounds are attacked by various nucleophiles containing different hetero atoms to obtain β-ketoesters, β-ketoamides and the corresponding β-keto-phosphorus compounds respectively. New β-ketoamides could be synthesized and characterized. The reaction of acylated Meldrum’s acid and diphenylphosphine did not lead to the expected β-keto-phosphide compound, but the resulting product could be identified as 3-acetyl-4-hydroxy-6-methylpyran-2-one.

UddannelserKemi, (Bachelor/kandidatuddannelse) Bachelor el. kandidat
Udgivelsesdato25 jan. 2007
VejledereFritz Duus


  • Meldrum’s acid
  • Nucleophiles Synthesis Product characterization