What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

Ole Vang, Nihal Ahmad, Clifton A. Baile, Joseph A. Baur, Karen Brown, Anna Csiszar, Dipak K. Das, Dominique Delmas, Carmem Gottfried, Hung-Yun Lin, Qing-Yong Ma, Partha Mukhopadhyay, Namasivayam Nalini, John M. Pezzuto, Tristan Richard, Yogeshwer Shukla, Young-Joon Surh, Thomas Szekeres, Thomas Szkudelski, Thomas WalleJoseph M. Wu

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Abstract

    BACKGROUND:

    Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark.
    METHODOLOGY:

    Literature search in databases as PUBMED and ISI Web of Science in combination with manual search was used to answer the following five questions: (1)Can resveratrol be recommended in the prevention or treatment of human diseases?; (2)Are there observed "side effects" caused by the intake of resveratrol in humans?; (3)What is the relevant dose of resveratrol?; (4)What valid data are available regarding an effect in various species of experimental animals?; (5)Which relevant (overall) mechanisms of action of resveratrol have been documented?
    CONCLUSIONS/SIGNIFICANCE:

    The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.
    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind6
    Udgave nummer6
    Antal sider11
    ISSN1932-6203
    DOI
    StatusUdgivet - 2011

    Emneord

    • Resveratrol

    Citer dette

    Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., Csiszar, A., Das, D. K., Delmas, D., Gottfried, C., Lin, H-Y., Ma, Q-Y., Mukhopadhyay, P., Nalini, N., Pezzuto, J. M., Richard, T., Shukla, Y., Surh, Y-J., Szekeres, T., Szkudelski, T., ... Wu, J. M. (2011). What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol. P L o S One, 6(6). https://doi.org/10.1371/journal.pone.0019881