Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

Kurt Fuursted, Lone Vedel Schøler, Frank Hansen, Karen Dam, Martin Saxtorph Bojer, Anette Hammerum, Frederik Dagnæs-Hansen, Anders Olsen, Yousef Jasemian, Carsten Struve

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.
    OriginalsprogEngelsk
    TidsskriftMicrobes and Infection
    Vol/bind14
    Udgave nummer2
    Sider (fra-til)155-158
    ISSN1286-4579
    DOI
    StatusUdgivet - feb. 2012

    Emneord

      Citer dette

      Fuursted, K., Schøler, L. V., Hansen, F., Dam, K., Bojer, M. S., Hammerum, A., ... Struve, C. (2012). Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1). Microbes and Infection, 14(2), 155-158. https://doi.org/10.1016/j.micinf.2011.08.015
      Fuursted, Kurt ; Schøler, Lone Vedel ; Hansen, Frank ; Dam, Karen ; Bojer, Martin Saxtorph ; Hammerum, Anette ; Dagnæs-Hansen, Frederik ; Olsen, Anders ; Jasemian, Yousef ; Struve, Carsten. / Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1). I: Microbes and Infection. 2012 ; Bind 14, Nr. 2. s. 155-158.
      @article{de73147c6ada4728bf9a70a35e3aea9e,
      title = "Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)",
      abstract = "The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.",
      keywords = "Klebsiella pneumoniae, New Delhi metallo-beta-lactamase-1, Virulence, Animal study, Caenorhabditis elegans",
      author = "Kurt Fuursted and Sch{\o}ler, {Lone Vedel} and Frank Hansen and Karen Dam and Bojer, {Martin Saxtorph} and Anette Hammerum and Frederik Dagn{\ae}s-Hansen and Anders Olsen and Yousef Jasemian and Carsten Struve",
      year = "2012",
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      doi = "10.1016/j.micinf.2011.08.015",
      language = "English",
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      journal = "Microbes and Infection",
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      Fuursted, K, Schøler, LV, Hansen, F, Dam, K, Bojer, MS, Hammerum, A, Dagnæs-Hansen, F, Olsen, A, Jasemian, Y & Struve, C 2012, 'Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)' Microbes and Infection, bind 14, nr. 2, s. 155-158. https://doi.org/10.1016/j.micinf.2011.08.015

      Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1). / Fuursted, Kurt; Schøler, Lone Vedel; Hansen, Frank; Dam, Karen; Bojer, Martin Saxtorph; Hammerum, Anette; Dagnæs-Hansen, Frederik; Olsen, Anders; Jasemian, Yousef; Struve, Carsten.

      I: Microbes and Infection, Bind 14, Nr. 2, 02.2012, s. 155-158.

      Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

      TY - JOUR

      T1 - Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

      AU - Fuursted, Kurt

      AU - Schøler, Lone Vedel

      AU - Hansen, Frank

      AU - Dam, Karen

      AU - Bojer, Martin Saxtorph

      AU - Hammerum, Anette

      AU - Dagnæs-Hansen, Frederik

      AU - Olsen, Anders

      AU - Jasemian, Yousef

      AU - Struve, Carsten

      PY - 2012/2

      Y1 - 2012/2

      N2 - The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.

      AB - The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.

      KW - Klebsiella pneumoniae

      KW - New Delhi metallo-beta-lactamase-1

      KW - Virulence

      KW - Animal study

      KW - Caenorhabditis elegans

      U2 - 10.1016/j.micinf.2011.08.015

      DO - 10.1016/j.micinf.2011.08.015

      M3 - Journal article

      VL - 14

      SP - 155

      EP - 158

      JO - Microbes and Infection

      JF - Microbes and Infection

      SN - 1286-4579

      IS - 2

      ER -