Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

Kurt Fuursted; Lone Vedel Schøler; Frank Hansen; Karen Dam; Martin Saxtorph Bojer; Anette Hammerum; Frederik Dagnæs-Hansen; Anders Olsen; Yousef Jasemian; Carsten Struve

doi:10.1016/j.micinf.2011.08.015

Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

Kurt Fuursted, Lone Vedel Schøler, Frank Hansen, Karen Dam, Martin Saxtorph Bojer, Anette Hammerum, Frederik Dagnæs-Hansen, Anders Olsen, Yousef Jasemian, Carsten Struve

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.

Originalsprog	Engelsk
Tidsskrift	Microbes and Infection
Vol/bind	14
Udgave nummer	2
Sider (fra-til)	155-158
ISSN	1286-4579
DOI	https://doi.org/10.1016/j.micinf.2011.08.015
Status	Udgivet - feb. 2012

Link til dokument

10.1016/j.micinf.2011.08.015

Citer dette

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abstract = "The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.",

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AU - Fuursted, Kurt

AU - Schøler, Lone Vedel

AU - Hansen, Frank

AU - Dam, Karen

AU - Bojer, Martin Saxtorph

AU - Hammerum, Anette

AU - Dagnæs-Hansen, Frederik

AU - Olsen, Anders

AU - Jasemian, Yousef

AU - Struve, Carsten

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AB - The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.

KW - Klebsiella pneumoniae

KW - New Delhi metallo-beta-lactamase-1

KW - Virulence

KW - Animal study

KW - Caenorhabditis elegans

U2 - 10.1016/j.micinf.2011.08.015

DO - 10.1016/j.micinf.2011.08.015

M3 - Journal article

SN - 1286-4579

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ER -