Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

Kurt Fuursted, Lone Vedel Schøler, Frank Hansen, Karen Dam, Martin Saxtorph Bojer, Anette Hammerum, Frederik Dagnæs-Hansen, Anders Olsen, Yousef Jasemian, Carsten Struve

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    Abstrakt

    The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.
    OriginalsprogEngelsk
    TidsskriftMicrobes and Infection
    Vol/bind14
    Udgave nummer2
    Sider (fra-til)155-158
    ISSN1286-4579
    DOI
    StatusUdgivet - feb. 2012

    Citer dette

    Fuursted, K., Schøler, L. V., Hansen, F., Dam, K., Bojer, M. S., Hammerum, A., ... Struve, C. (2012). Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1). Microbes and Infection, 14(2), 155-158. https://doi.org/10.1016/j.micinf.2011.08.015