Use of NMR in profiling of cocaine seizures

Bruno Pagano, Ilaria Lauri, Stefano De Tito, Guido Persico, Maria Giovanna Chini, Anders Malmendal, Ettore Novellino, Antonio Randazzo

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical "fingerprint" of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical "fingerprint" depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.
OriginalsprogEngelsk
TidsskriftForensic Science International
Vol/bind231
Udgave nummer1-3
Sider (fra-til)120-4
Antal sider5
ISSN0379-0738
DOI
StatusUdgivet - 10 sep. 2013
Udgivet eksterntJa

Citer dette

Pagano, B., Lauri, I., De Tito, S., Persico, G., Chini, M. G., Malmendal, A., ... Randazzo, A. (2013). Use of NMR in profiling of cocaine seizures. Forensic Science International, 231(1-3), 120-4. https://doi.org/10.1016/j.forsciint.2013.04.028
Pagano, Bruno ; Lauri, Ilaria ; De Tito, Stefano ; Persico, Guido ; Chini, Maria Giovanna ; Malmendal, Anders ; Novellino, Ettore ; Randazzo, Antonio. / Use of NMR in profiling of cocaine seizures. I: Forensic Science International. 2013 ; Bind 231, Nr. 1-3. s. 120-4.
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title = "Use of NMR in profiling of cocaine seizures",
abstract = "Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical {"}fingerprint{"} of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical {"}fingerprint{"} depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.",
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Pagano, B, Lauri, I, De Tito, S, Persico, G, Chini, MG, Malmendal, A, Novellino, E & Randazzo, A 2013, 'Use of NMR in profiling of cocaine seizures', Forensic Science International, bind 231, nr. 1-3, s. 120-4. https://doi.org/10.1016/j.forsciint.2013.04.028

Use of NMR in profiling of cocaine seizures. / Pagano, Bruno; Lauri, Ilaria; De Tito, Stefano; Persico, Guido; Chini, Maria Giovanna; Malmendal, Anders; Novellino, Ettore; Randazzo, Antonio.

I: Forensic Science International, Bind 231, Nr. 1-3, 10.09.2013, s. 120-4.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Use of NMR in profiling of cocaine seizures

AU - Pagano, Bruno

AU - Lauri, Ilaria

AU - De Tito, Stefano

AU - Persico, Guido

AU - Chini, Maria Giovanna

AU - Malmendal, Anders

AU - Novellino, Ettore

AU - Randazzo, Antonio

N1 - Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/9/10

Y1 - 2013/9/10

N2 - Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical "fingerprint" of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical "fingerprint" depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.

AB - Cocaine is the most widely used illicit drug, and its origin is always the focus of intense investigation aimed at identifying the trafficking routes. Since NMR represents a unique methodology for performing chemical identification and quantification, here it is proposed a strategy based on (1)H NMR spectral analysis in conjunction with multivariate analysis to identify the chemical "fingerprint" of cocaine samples, and to link cocaine samples based on this information. The most relevant spectral regions containing the fingerprint have been identified: δH 0.86-0.96, 1.50-1.56, 5.90-5.93, 6.48-6.52, 7.31-7.34, 7.61-7.63, 7.68-7.72ppm. The strategy has been applied on samples seized in different times and places in Naples (Italy). The chemical "fingerprint" depend on what plant they were extracted from, where it was cultivated, and which procedures were used for extraction and purification, thus adding significant information in the process toward identification of the trafficking routes for this drug.

U2 - 10.1016/j.forsciint.2013.04.028

DO - 10.1016/j.forsciint.2013.04.028

M3 - Journal article

VL - 231

SP - 120

EP - 124

JO - Forensic Science International

JF - Forensic Science International

SN - 0379-0738

IS - 1-3

ER -

Pagano B, Lauri I, De Tito S, Persico G, Chini MG, Malmendal A et al. Use of NMR in profiling of cocaine seizures. Forensic Science International. 2013 sep 10;231(1-3):120-4. https://doi.org/10.1016/j.forsciint.2013.04.028