Ultrasound-Accelerated Synthesis of Asymmetrical Thiosulfonate S-Esters by Base-Promoted Reaction of Sulfonyl Chlorides with Thiols

Hien Thi Pham, Ngoc-Lan Thi Nguyen, Fritz Duus, Thi Xuan Thi Luu

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    Amberlyst A-26, Mg-Al hydrotalcite, potassium fluoride absorbed on alumina, triethylamine and pyridine have been tested as base catalysts and reagents for the reaction of sulfonyl chlorides with thiols to prepare thiosulfonate S-esters. The reactions were performed under solvent-free conditions or with a minimum amount of solvent assisted by magnetic stirring, ultrasound irradiation and microwave irradiation. Ultrasound irradiation has good effects on the synthesis of sterically hindered thiosulfonate S-esters in solvent-free media as well as in a minimum amount of anhydrous diethyl ether.
    TidsskriftPhosphorus, Sulfur and Silicon and the Related Elements
    Udgave nummer11
    Sider (fra-til)1934-1941
    StatusUdgivet - 2015


    • Thiosulfonates
    • thiols
    • sulfonyl chlorides
    • triethylamine
    • ultrasound irradiation

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