Ultrasound accelerated sulfonylation of amines by p-acetamidobenzenesulfonyl chloride using Mg–Al hydrotalcite as an efficient green base catalyst

Binh Nhat Truong, Luong Huu Le, Duy-Khiem Nguyen Chau, Fritz Duus, Thi Xuan Thi Luu

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Abstract

The sulfonylation reaction of various aliphatic, alicyclic, aromatic, and hetero-aromatic amines with p-acetamidobenzenesulfonyl chloride has been investigated using different types of base catalysis under varied reaction conditions. Mg–Al hydrotalcite, characterizable as an inexpensive, reusable, and green solid catalyst, was found to be the most efficient catalyst, when the reaction is carried out in a minimum volume of solvent (acetone). The reaction was found to be accelerated drastically with the support of ultrasound irradiation, affording the sulfonamides in yields better or equivalent to those obtained under the longer lasting conventional stirring conditions.
OriginalsprogEngelsk
TidsskriftJournal of Sulfur Chemistry
Vol/bind37
Udgave nummer5
Sider (fra-til)515-528
ISSN1741-5993
DOI
StatusUdgivet - 2016

Emneord

  • Mg–Al hydrotalcite
  • sulfonamide synthesis
  • disulfonylation of amine
  • desulfonylation
  • ultrasound irradiation

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