Type 2 diabetes models

Dorte Xenia Gram

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

    Abstract

    This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models and in principle they can be combined in various ways. The comprehensive listing of all relevant tests and models is too long to be discussed and described in detail here. Therefore, a few selected in vivo experiments (author's models of choice) are described. These are acute experiments after single dose of the TRP antagonist in rodents and could/should be repeated after chronic dosing. Non-rodent models are briefly discussed, and a single model and test are suggested but not described in detail. The experiments are aiming at demonstrating that the TRP antagonists are effective in treating hyperglycemia, impaired glucose tolerance, impaired insulin secretion, and insulin resistance in vivo and should, thus, be sufficient to demonstrate preclinical proof of concept of a TRP antagonist in type 2 diabetes in rodents. The experiments are suggestions and could be replaced or supplemented by others.
    OriginalsprogEngelsk
    TitelMethods in Pharmacology and Toxicology
    RedaktørerA. Szallasi, T. Biro
    Vol/bind2012
    Udgivelses stedNew York
    ForlagSpringer
    Publikationsdato2012
    Sider319-332
    ISBN (Trykt)978-162703094-6
    DOI
    StatusUdgivet - 2012
    NavnMethods in Pharmacology and Toxicology
    ISSN1557-2153

    Citer dette

    Gram, D. X. (2012). Type 2 diabetes models. I A. Szallasi, & T. Biro (red.), Methods in Pharmacology and Toxicology (Bind 2012, s. 319-332). Springer. Methods in Pharmacology and Toxicology https://doi.org/10.1007/978-1-62703-095-3_20