Two new sesquiterpenes from the stems of Miliusa velutina

Truong Van Nguyen Thien, Thi Kieu Loan Vo, Phu Hoang Dang, Vinh Huynh Ngoc, Thi Thuy Duong Ngo, Thi My-Nuong Nguyen, Poul Erik Hansen, Quang Ton That

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

From the ethyl acetate extract of the stems of Miliusa velutina, seven compounds (1–7) were isolated, including two new compounds such as mivelutina A acid (1), mivelutina B acid (2) and one known compound mivelutina B methyl ester (3). For this NMR data were not known previously. Their relative structures were elucidated based on NMR spectroscopic analysis. The absolute configuartions were determined based on DFT calculations of 13C chemical shifts. All of the seven compounds were screened for their in vitro cytotoxic activities against HepG2 cell line using the SRB assay. Epoxyconiferyl alcohol (7) showed the highest potential for the cytotoxicity of cancer cell lines HepG2 with the IC50 values of 95.94 μg/mL (527 μM).
OriginalsprogDansk
TidsskriftNatural Product Research
Sider (fra-til)1-7
Antal sider8
ISSN1478-6419
StatusUdgivet - 15 jul. 2020

Emneord

  • sesquiterpenes
  • DFT calculations
  • absolute configuration

Citer dette

Van Nguyen Thien, T., Vo, T. K. L., Dang, P. H., Ngoc, V. H., Ngo, T. T. D., Nguyen, T. M-N., Hansen, P. E., & That, Q. T. (2020). Two new sesquiterpenes from the stems of Miliusa velutina. Natural Product Research, 1-7.