Transportation Noise Pollution and Cardiovascular Health

Thomas Münzel*, Michael Molitor, Marin Kuntic, Omar Hahad, Martin Röösli, Nicole Engelmann, Mathias Basner, Andreas Daiber, Mette Sørensen

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Epidemiological studies have found that transportation noise increases the risk for cardiovascular morbidity and mortality, with solid evidence for ischemic heart disease, heart failure, and stroke. According to the World Health Organization, at least 1.6 million healthy life years are lost annually from traffic-related noise in Western Europe. Traffic noise at night causes fragmentation and shortening of sleep, elevation of stress hormone levels, and increased oxidative stress in the vasculature and the brain. These factors can promote vascular (endothelial) dysfunction, inflammation, and arterial hypertension, thus elevating cardiovascular risk. The present review focusses on the indirect, nonauditory cardiovascular health effects of noise. We provide an updated overview of epidemiological research on the effects of transportation noise on cardiovascular risk factors and disease, and mechanistic insights based on the latest clinical and experimental studies and propose new risk markers to address noise-induced cardiovascular effects in the general population. We will discuss the potential effects of noise on vascular dysfunction, oxidative stress, and inflammation in humans and animals. We will elaborately explain the underlying pathomechanisms by alterations of gene networks, epigenetic pathways, circadian rhythm, signal transduction along the neuronal-cardiovascular axis, and metabolism. We will describe current and future noise mitigation strategies. Finally, we will conduct an overall evaluation of the status of the current evidence of noise as a significant cardiovascular risk factor.

OriginalsprogEngelsk
TidsskriftCirculation Research
Vol/bind134
Udgave nummer9
Sider (fra-til)1113-1135
Antal sider23
ISSN0009-7330
DOI
StatusUdgivet - 25 apr. 2024

Bibliografisk note

Funding Information:
Drs M\u00FCnzel and Daiber were supported by vascular biology research grants from the Boehringer Ingelheim Foundation for the collaborative research group, novel and neglected cardiovascular risk factors: molecular mechanisms and therapeutics, and through continuous research support from the Foundation Heart of Mainz . The Umbrella+ review was partly funded by the European Environmental Agency as part of a grant with the European Topic Centre on Human health and the Environment to the Swiss Tropical and Public Health Institute.

Funding Information:
the Foundation Heart of Mainz. The Umbrella+ review was partly funded by the European Environmental Agency as part of a grant with the European Topic Centre on Human health and the Environment to the Swiss Tropical and Public Health Institute

Emneord

  • biological availability
  • blood pressure
  • monocytes
  • mortality, premature
  • nitric oxide

Citer dette