Trained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNβ-1a

George D Vavougios*, Theodore Mavridis, Artemios Artemiadis, Karen A Krogfelt, Georgios Hadjigeorgiou

*Corresponding author

Publikation: Bidrag til tidsskriftReviewpeer review


Type I interferon (IFN-I) signalling represents a major target for modulation in a virus' bid for latency. IFN-I perturbations are also present in such as Alzheimer's disease (AD) and multiple sclerosis (MS), where viral infections are known to increase symptomatic burden. IFN-I modulation such as via IFNβ-1a, an established MS treatment, has been researched to a limited extent to both AD and COVID-19. In this mini review, we present emerging research on trained immunity as a pathogenetic basis for Alzheimer's disease and the emerging context for IFNβ-1a repositioning, via mechanisms shared with multiple sclerosis and induced by viral infections.
TidsskriftB B A - Molecular Basis of Disease
Udgave nummer9
Sider (fra-til)166430
Antal sider1
StatusUdgivet - 1 sep. 2022

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