The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

Majken Karoline Jensen, Eric B. Rimm, Kenneth J. Mukamal, Andrew C. Edmondson, Daniel J. Rader, Ulla Vogel, Anne Tjønneland, Thorkild I.A. Sørensen, Erik Berg Schmidt, Kim Overvad

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women.

    The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele.

    Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.

    OriginalsprogEngelsk
    TidsskriftEuropean Heart Journal
    Vol/bind30
    Udgave nummer13
    Sider (fra-til)1584-1589
    ISSN0195-668X
    DOI
    StatusUdgivet - 2009

    Citer dette

    Jensen, M. K., Rimm, E. B., Mukamal, K. J., Edmondson, A. C., Rader, D. J., Vogel, U., ... Overvad, K. (2009). The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. European Heart Journal, 30(13), 1584-1589. https://doi.org/10.1093/eurheartj/ehp145
    Jensen, Majken Karoline ; Rimm, Eric B. ; Mukamal, Kenneth J. ; Edmondson, Andrew C. ; Rader, Daniel J. ; Vogel, Ulla ; Tjønneland, Anne ; Sørensen, Thorkild I.A. ; Schmidt, Erik Berg ; Overvad, Kim. / The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. I: European Heart Journal. 2009 ; Bind 30, Nr. 13. s. 1584-1589.
    @article{f96a26b0f9f911de89af000ea68e967b,
    title = "The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations",
    abstract = "Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele.Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.",
    keywords = "Genetic epidemiology, Endothelial lipase, HDL-cholesterol, CHD-risk",
    author = "Jensen, {Majken Karoline} and Rimm, {Eric B.} and Mukamal, {Kenneth J.} and Edmondson, {Andrew C.} and Rader, {Daniel J.} and Ulla Vogel and Anne Tj{\o}nneland and S{\o}rensen, {Thorkild I.A.} and Schmidt, {Erik Berg} and Kim Overvad",
    year = "2009",
    doi = "10.1093/eurheartj/ehp145",
    language = "English",
    volume = "30",
    pages = "1584--1589",
    journal = "European Heart Journal",
    issn = "0195-668X",
    publisher = "Oxford University Press",
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    Jensen, MK, Rimm, EB, Mukamal, KJ, Edmondson, AC, Rader, DJ, Vogel, U, Tjønneland, A, Sørensen, TIA, Schmidt, EB & Overvad, K 2009, 'The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations', European Heart Journal, bind 30, nr. 13, s. 1584-1589. https://doi.org/10.1093/eurheartj/ehp145

    The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. / Jensen, Majken Karoline; Rimm, Eric B.; Mukamal, Kenneth J.; Edmondson, Andrew C.; Rader, Daniel J.; Vogel, Ulla; Tjønneland, Anne; Sørensen, Thorkild I.A.; Schmidt, Erik Berg; Overvad, Kim.

    I: European Heart Journal, Bind 30, Nr. 13, 2009, s. 1584-1589.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

    AU - Jensen, Majken Karoline

    AU - Rimm, Eric B.

    AU - Mukamal, Kenneth J.

    AU - Edmondson, Andrew C.

    AU - Rader, Daniel J.

    AU - Vogel, Ulla

    AU - Tjønneland, Anne

    AU - Sørensen, Thorkild I.A.

    AU - Schmidt, Erik Berg

    AU - Overvad, Kim

    PY - 2009

    Y1 - 2009

    N2 - Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele.Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.

    AB - Endothelial lipase (LIPG) is implicated in the metabolism of high-density lipoprotein cholesterol (HDL-C). Small studies in selected populations have reported higher HDL-C levels among carriers of the common T111I variant in LIPG, but whether this variant is associated with plasma lipids and risk of coronary heart disease (CHD) in the general population is unclear. The objective of this study was to address the associations of the T111I variant with plasma lipids and risk of CHD in three independent prospective studies of generally healthy men and women. The T111I variant was genotyped in case-control studies of CHD nested within the Diet, Cancer, and Health study with 998 cases, Nurses' Health Study with 241 cases, and Health Professionals Follow-up Study with 262 cases. The minor allele frequency in the combined pool of controls was 0.29. The T111I variant was not associated with HDL-C or any other lipid and lipoprotein measures. Compared with wildtype homozygotes, the pooled estimate for risk of CHD was 0.95 (0.85-1.06) per T111I allele.Our analysis among healthy Caucasian men and women from three independent studies does not support an association between the T111I variant and HDL-C, other plasma lipids, or risk of CHD.

    KW - Genetic epidemiology

    KW - Endothelial lipase

    KW - HDL-cholesterol

    KW - CHD-risk

    U2 - 10.1093/eurheartj/ehp145

    DO - 10.1093/eurheartj/ehp145

    M3 - Journal article

    VL - 30

    SP - 1584

    EP - 1589

    JO - European Heart Journal

    JF - European Heart Journal

    SN - 0195-668X

    IS - 13

    ER -