The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis

Simon Metz Pedersen, Niels Chr Nielsen, Henrik J Andersen, Johan Olsson, Magnus Simrén, Lena Ohman, Ulla Svensson, Anders Malmendal, Hanne Christine S. Bertram

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Abstract

The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using (1)H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum L-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level.
OriginalsprogEngelsk
TidsskriftNutrients
Vol/bind2
Udgave nummer11
Sider (fra-til)1141-55
Antal sider15
ISSN2072-6643
DOI
StatusUdgivet - 2010
Udgivet eksterntJa

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