The Prognostic Value of Polycomb Group Protein BMI1 in Stage II Colon Cancer Patients

Maiken Lise Marcker Espersen, Dorte Linnemann, Ib J. Christensen, Mahdi Alamili, Jesper Troelsen, Estrid Høgdall

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The aim of this study was to investigate the prognostic value of B-cell-specific moloney murine leukemia virus insertion site 1 (BMI1) protein expression in primary tumors of stage II colon cancer patients. BMI1 protein expression was assessed by immunohistochemistry in a retrospective patient cohort consisting of 144 stage II colon cancer patients. BMI1 expression at the invasive front of the primary tumors correlated with mismatch repair status of the tumors. Furthermore, BMI1 expression at the luminal surface correlated with T-stage, tumor location, and the histological subtypes of the tumors. In a univariate Cox proportional hazard analysis, no statistical significant association between risk of relapse and BMI1 protein expression at the invasive front (HR: 1.12; 95% CI 0.78-1.60; p = 0.53) or at the luminal surface of the tumor (HR: 1.06; 95% CI 0.75-1.48; p = 0.70) was found. Likewise, there was no association between 5-year overall survival and BMI1 expression at the invasive front (HR: 1.12; 95% CI 0.80-1.56; p = 0.46) or at the luminal surface of the tumor (HR: 1.16; 95% CI 0.86-1.60; p = 0.33). In conclusion, BMI1 expression in primary tumors of stage II colon cancer patients could not predict relapse or overall survival of the patients, thus having a limited prognostic value in stage II colon cancer patients.
OriginalsprogEngelsk
TidsskriftA P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Vol/bind124
Udgave nummer7
Sider (fra-til)541-546
ISSN0903-4641
DOI
StatusUdgivet - 2016

Citer dette

Espersen, Maiken Lise Marcker ; Linnemann, Dorte ; Christensen, Ib J. ; Alamili, Mahdi ; Troelsen, Jesper ; Høgdall, Estrid. / The Prognostic Value of Polycomb Group Protein BMI1 in Stage II Colon Cancer Patients. I: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 2016 ; Bind 124, Nr. 7. s. 541-546.
@article{b60674a415d74e48977505f28dba293c,
title = "The Prognostic Value of Polycomb Group Protein BMI1 in Stage II Colon Cancer Patients",
abstract = "The aim of this study was to investigate the prognostic value of B-cell-specific moloney murine leukemia virus insertion site 1 (BMI1) protein expression in primary tumors of stage II colon cancer patients. BMI1 protein expression was assessed by immunohistochemistry in a retrospective patient cohort consisting of 144 stage II colon cancer patients. BMI1 expression at the invasive front of the primary tumors correlated with mismatch repair status of the tumors. Furthermore, BMI1 expression at the luminal surface correlated with T-stage, tumor location, and the histological subtypes of the tumors. In a univariate Cox proportional hazard analysis, no statistical significant association between risk of relapse and BMI1 protein expression at the invasive front (HR: 1.12; 95{\%} CI 0.78-1.60; p = 0.53) or at the luminal surface of the tumor (HR: 1.06; 95{\%} CI 0.75-1.48; p = 0.70) was found. Likewise, there was no association between 5-year overall survival and BMI1 expression at the invasive front (HR: 1.12; 95{\%} CI 0.80-1.56; p = 0.46) or at the luminal surface of the tumor (HR: 1.16; 95{\%} CI 0.86-1.60; p = 0.33). In conclusion, BMI1 expression in primary tumors of stage II colon cancer patients could not predict relapse or overall survival of the patients, thus having a limited prognostic value in stage II colon cancer patients.",
author = "Espersen, {Maiken Lise Marcker} and Dorte Linnemann and Christensen, {Ib J.} and Mahdi Alamili and Jesper Troelsen and Estrid H{\o}gdall",
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The Prognostic Value of Polycomb Group Protein BMI1 in Stage II Colon Cancer Patients. / Espersen, Maiken Lise Marcker; Linnemann, Dorte; Christensen, Ib J.; Alamili, Mahdi; Troelsen, Jesper; Høgdall, Estrid.

I: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Bind 124, Nr. 7, 2016, s. 541-546.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The Prognostic Value of Polycomb Group Protein BMI1 in Stage II Colon Cancer Patients

AU - Espersen, Maiken Lise Marcker

AU - Linnemann, Dorte

AU - Christensen, Ib J.

AU - Alamili, Mahdi

AU - Troelsen, Jesper

AU - Høgdall, Estrid

PY - 2016

Y1 - 2016

N2 - The aim of this study was to investigate the prognostic value of B-cell-specific moloney murine leukemia virus insertion site 1 (BMI1) protein expression in primary tumors of stage II colon cancer patients. BMI1 protein expression was assessed by immunohistochemistry in a retrospective patient cohort consisting of 144 stage II colon cancer patients. BMI1 expression at the invasive front of the primary tumors correlated with mismatch repair status of the tumors. Furthermore, BMI1 expression at the luminal surface correlated with T-stage, tumor location, and the histological subtypes of the tumors. In a univariate Cox proportional hazard analysis, no statistical significant association between risk of relapse and BMI1 protein expression at the invasive front (HR: 1.12; 95% CI 0.78-1.60; p = 0.53) or at the luminal surface of the tumor (HR: 1.06; 95% CI 0.75-1.48; p = 0.70) was found. Likewise, there was no association between 5-year overall survival and BMI1 expression at the invasive front (HR: 1.12; 95% CI 0.80-1.56; p = 0.46) or at the luminal surface of the tumor (HR: 1.16; 95% CI 0.86-1.60; p = 0.33). In conclusion, BMI1 expression in primary tumors of stage II colon cancer patients could not predict relapse or overall survival of the patients, thus having a limited prognostic value in stage II colon cancer patients.

AB - The aim of this study was to investigate the prognostic value of B-cell-specific moloney murine leukemia virus insertion site 1 (BMI1) protein expression in primary tumors of stage II colon cancer patients. BMI1 protein expression was assessed by immunohistochemistry in a retrospective patient cohort consisting of 144 stage II colon cancer patients. BMI1 expression at the invasive front of the primary tumors correlated with mismatch repair status of the tumors. Furthermore, BMI1 expression at the luminal surface correlated with T-stage, tumor location, and the histological subtypes of the tumors. In a univariate Cox proportional hazard analysis, no statistical significant association between risk of relapse and BMI1 protein expression at the invasive front (HR: 1.12; 95% CI 0.78-1.60; p = 0.53) or at the luminal surface of the tumor (HR: 1.06; 95% CI 0.75-1.48; p = 0.70) was found. Likewise, there was no association between 5-year overall survival and BMI1 expression at the invasive front (HR: 1.12; 95% CI 0.80-1.56; p = 0.46) or at the luminal surface of the tumor (HR: 1.16; 95% CI 0.86-1.60; p = 0.33). In conclusion, BMI1 expression in primary tumors of stage II colon cancer patients could not predict relapse or overall survival of the patients, thus having a limited prognostic value in stage II colon cancer patients.

U2 - 10.1111/apm.12539

DO - 10.1111/apm.12539

M3 - Journal article

VL - 124

SP - 541

EP - 546

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 7

ER -