The Population Genetics of Antibiotic Resistance

B. R. Levin, M. Lipsitch, V. Perrot, S. Schrag, R. Antia, Lone Simonsen, N. Moore Walker, F. M. Stewart

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the commensal flora of human hosts, as well as the rates at which these frequencies would decline following a cessation of antibiotic use. Recent studies of the population biology of plasmid-encoded and chromosomal antibiotic resistance are reviewed for estimates of the parameters of these models and to evaluate other factors contributing to the fate of antibiotic-resistant bacteria in human hosts. The implications of these theoretical and empirical results to the future of antibacterial chemotherapy are discussed.
OriginalsprogEngelsk
TidsskriftClinical Infectious Diseases
Vol/bind24
Udgave nummer1
Antal sider8
StatusUdgivet - 1997
Udgivet eksterntJa

Citer dette

Levin, B. R., Lipsitch, M., Perrot, V., Schrag, S., Antia, R., Simonsen, L., ... Stewart, F. M. (1997). The Population Genetics of Antibiotic Resistance. Clinical Infectious Diseases, 24(1).
Levin, B. R. ; Lipsitch, M. ; Perrot, V. ; Schrag, S. ; Antia, R. ; Simonsen, Lone ; Moore Walker, N. ; Stewart, F. M. / The Population Genetics of Antibiotic Resistance. I: Clinical Infectious Diseases. 1997 ; Bind 24, Nr. 1.
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Levin, BR, Lipsitch, M, Perrot, V, Schrag, S, Antia, R, Simonsen, L, Moore Walker, N & Stewart, FM 1997, 'The Population Genetics of Antibiotic Resistance', Clinical Infectious Diseases, bind 24, nr. 1.

The Population Genetics of Antibiotic Resistance. / Levin, B. R. ; Lipsitch, M.; Perrot, V.; Schrag, S.; Antia, R.; Simonsen, Lone; Moore Walker, N. ; Stewart, F. M.

I: Clinical Infectious Diseases, Bind 24, Nr. 1, 1997.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The Population Genetics of Antibiotic Resistance

AU - Levin, B. R.

AU - Lipsitch, M.

AU - Perrot, V.

AU - Schrag, S.

AU - Antia, R.

AU - Simonsen, Lone

AU - Moore Walker, N.

AU - Stewart, F. M.

PY - 1997

Y1 - 1997

N2 - Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the commensal flora of human hosts, as well as the rates at which these frequencies would decline following a cessation of antibiotic use. Recent studies of the population biology of plasmid-encoded and chromosomal antibiotic resistance are reviewed for estimates of the parameters of these models and to evaluate other factors contributing to the fate of antibiotic-resistant bacteria in human hosts. The implications of these theoretical and empirical results to the future of antibacterial chemotherapy are discussed.

AB - Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the commensal flora of human hosts, as well as the rates at which these frequencies would decline following a cessation of antibiotic use. Recent studies of the population biology of plasmid-encoded and chromosomal antibiotic resistance are reviewed for estimates of the parameters of these models and to evaluate other factors contributing to the fate of antibiotic-resistant bacteria in human hosts. The implications of these theoretical and empirical results to the future of antibacterial chemotherapy are discussed.

M3 - Journal article

VL - 24

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -

Levin BR, Lipsitch M, Perrot V, Schrag S, Antia R, Simonsen L et al. The Population Genetics of Antibiotic Resistance. Clinical Infectious Diseases. 1997;24(1).