The phomactins: A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes

W. P. D. Goldring, G. Pattenden

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

A description of the structurally unusual “phomactin” family of platelet activating factor antagonists recently found in the marine fungus Phoma sp. is presented. The phomactins show an interesting structural and biosynthetic relationship with the more familiar taxane group of antitumor compounds isolated from yew trees. The Account highlights and discusses this unique relationship and also presents a cogent picture of plausible biogenetic interrelationships within the family of phomactins. Complementary synthetic endeavors with the phomactins are interwoven in the discussions, alongside contemporaneous biosynthetic studies with both the phomactins and the taxanes.
OriginalsprogEngelsk
TidsskriftAccounts of Chemical Research
Vol/bind39
Udgave nummer5
Sider (fra-til)354-361
Antal sider8
ISSN0001-4842
DOI
StatusUdgivet - 2006
Udgivet eksterntJa

Citer dette

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abstract = "A description of the structurally unusual “phomactin” family of platelet activating factor antagonists recently found in the marine fungus Phoma sp. is presented. The phomactins show an interesting structural and biosynthetic relationship with the more familiar taxane group of antitumor compounds isolated from yew trees. The Account highlights and discusses this unique relationship and also presents a cogent picture of plausible biogenetic interrelationships within the family of phomactins. Complementary synthetic endeavors with the phomactins are interwoven in the discussions, alongside contemporaneous biosynthetic studies with both the phomactins and the taxanes.",
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The phomactins : A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes. / Goldring, W. P. D.; Pattenden, G.

I: Accounts of Chemical Research, Bind 39, Nr. 5, 2006, s. 354-361.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The phomactins

T2 - A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes

AU - Goldring, W. P. D.

AU - Pattenden, G.

PY - 2006

Y1 - 2006

N2 - A description of the structurally unusual “phomactin” family of platelet activating factor antagonists recently found in the marine fungus Phoma sp. is presented. The phomactins show an interesting structural and biosynthetic relationship with the more familiar taxane group of antitumor compounds isolated from yew trees. The Account highlights and discusses this unique relationship and also presents a cogent picture of plausible biogenetic interrelationships within the family of phomactins. Complementary synthetic endeavors with the phomactins are interwoven in the discussions, alongside contemporaneous biosynthetic studies with both the phomactins and the taxanes.

AB - A description of the structurally unusual “phomactin” family of platelet activating factor antagonists recently found in the marine fungus Phoma sp. is presented. The phomactins show an interesting structural and biosynthetic relationship with the more familiar taxane group of antitumor compounds isolated from yew trees. The Account highlights and discusses this unique relationship and also presents a cogent picture of plausible biogenetic interrelationships within the family of phomactins. Complementary synthetic endeavors with the phomactins are interwoven in the discussions, alongside contemporaneous biosynthetic studies with both the phomactins and the taxanes.

U2 - 10.1021/ar050186c

DO - 10.1021/ar050186c

M3 - Journal article

VL - 39

SP - 354

EP - 361

JO - Accounts of Chemical Research

JF - Accounts of Chemical Research

SN - 0001-4842

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