The phomactins: A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes

W. P. D. Goldring, G. Pattenden

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

A description of the structurally unusual “phomactin” family of platelet activating factor antagonists recently found in the marine fungus Phoma sp. is presented. The phomactins show an interesting structural and biosynthetic relationship with the more familiar taxane group of antitumor compounds isolated from yew trees. The Account highlights and discusses this unique relationship and also presents a cogent picture of plausible biogenetic interrelationships within the family of phomactins. Complementary synthetic endeavors with the phomactins are interwoven in the discussions, alongside contemporaneous biosynthetic studies with both the phomactins and the taxanes.
OriginalsprogEngelsk
TidsskriftAccounts of Chemical Research
Vol/bind39
Udgave nummer5
Sider (fra-til)354-361
Antal sider8
ISSN0001-4842
DOI
StatusUdgivet - 2006
Udgivet eksterntJa

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