The Immunomodulation Effect of Aronia Extract Lacks Association with Its Antioxidant Anthocyanins

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Polyphenols comprise a diverse group of molecules with antioxidative and anti-inflammatory activities. To compare the antioxidative and anti-inflammatory capacity of Aronia melanocarpa berries (chokeberries), recognized for their high content of anthocyanins, a noncytotoxic isolation method was developed to obtain high-purity anthocyanins in the extract. The antioxidative activity of the extract, the anthocyanin-rich fraction (AF) was determined by 1,1-diphenyl-2-picrylhydrazyl radical and ferric-reducing ability of plasma along with resveratrol as a reference. The immunomodulation properties were assessed in lipopolysaccharide (LPS)-stimulated human monocytes mono mac 6. The isolated AF, containing six different anthocyanins, exhibited a stronger antioxidative capacity compared to resveratrol. Resveratrol enhanced tumor necrosis factor-alpha and reduced interleukin-10 (IL-10) production by LPS, whereas AF only had a slight effect in reducing IL-10. These results demonstrated that there was no major relationship between the antioxidative effect and immunomodulation capacities of AF and resveratrol. The immunomodulatory activity of the extract is associated with bioactive compounds in Aronia other than its anthocyanins.
    OriginalsprogEngelsk
    TidsskriftJournal of Medicinal Food
    Vol/bind16
    Udgave nummer4
    Sider (fra-til)334-342
    ISSN1096-620X
    DOI
    StatusUdgivet - 2013

    Emneord

    • anthocyanins
    • anti-inflammatory
    • antioxidative
    • Aronia
    • resveratrol

    Citer dette

    @article{84e1482c1f2c4029b63a365c1115120f,
    title = "The Immunomodulation Effect of Aronia Extract Lacks Association with Its Antioxidant Anthocyanins",
    abstract = "Polyphenols comprise a diverse group of molecules with antioxidative and anti-inflammatory activities. To compare the antioxidative and anti-inflammatory capacity of Aronia melanocarpa berries (chokeberries), recognized for their high content of anthocyanins, a noncytotoxic isolation method was developed to obtain high-purity anthocyanins in the extract. The antioxidative activity of the extract, the anthocyanin-rich fraction (AF) was determined by 1,1-diphenyl-2-picrylhydrazyl radical and ferric-reducing ability of plasma along with resveratrol as a reference. The immunomodulation properties were assessed in lipopolysaccharide (LPS)-stimulated human monocytes mono mac 6. The isolated AF, containing six different anthocyanins, exhibited a stronger antioxidative capacity compared to resveratrol. Resveratrol enhanced tumor necrosis factor-alpha and reduced interleukin-10 (IL-10) production by LPS, whereas AF only had a slight effect in reducing IL-10. These results demonstrated that there was no major relationship between the antioxidative effect and immunomodulation capacities of AF and resveratrol. The immunomodulatory activity of the extract is associated with bioactive compounds in Aronia other than its anthocyanins.",
    keywords = "anthocyanins, anti-inflammatory, antioxidative, Aronia, resveratrol, anthocyanins, anti-inflammatory, antioxidative, Aronia, resveratrol",
    author = "Biljana Mojsoska and Jin Xu",
    year = "2013",
    doi = "10.1089/jmf.2012.0151",
    language = "English",
    volume = "16",
    pages = "334--342",
    journal = "Journal of Medicinal Food",
    issn = "1096-620X",
    publisher = "Mary AnnLiebert, Inc. Publishers",
    number = "4",

    }

    The Immunomodulation Effect of Aronia Extract Lacks Association with Its Antioxidant Anthocyanins. / Mojsoska, Biljana; Xu, Jin.

    I: Journal of Medicinal Food, Bind 16, Nr. 4, 2013, s. 334-342.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - The Immunomodulation Effect of Aronia Extract Lacks Association with Its Antioxidant Anthocyanins

    AU - Mojsoska, Biljana

    AU - Xu, Jin

    PY - 2013

    Y1 - 2013

    N2 - Polyphenols comprise a diverse group of molecules with antioxidative and anti-inflammatory activities. To compare the antioxidative and anti-inflammatory capacity of Aronia melanocarpa berries (chokeberries), recognized for their high content of anthocyanins, a noncytotoxic isolation method was developed to obtain high-purity anthocyanins in the extract. The antioxidative activity of the extract, the anthocyanin-rich fraction (AF) was determined by 1,1-diphenyl-2-picrylhydrazyl radical and ferric-reducing ability of plasma along with resveratrol as a reference. The immunomodulation properties were assessed in lipopolysaccharide (LPS)-stimulated human monocytes mono mac 6. The isolated AF, containing six different anthocyanins, exhibited a stronger antioxidative capacity compared to resveratrol. Resveratrol enhanced tumor necrosis factor-alpha and reduced interleukin-10 (IL-10) production by LPS, whereas AF only had a slight effect in reducing IL-10. These results demonstrated that there was no major relationship between the antioxidative effect and immunomodulation capacities of AF and resveratrol. The immunomodulatory activity of the extract is associated with bioactive compounds in Aronia other than its anthocyanins.

    AB - Polyphenols comprise a diverse group of molecules with antioxidative and anti-inflammatory activities. To compare the antioxidative and anti-inflammatory capacity of Aronia melanocarpa berries (chokeberries), recognized for their high content of anthocyanins, a noncytotoxic isolation method was developed to obtain high-purity anthocyanins in the extract. The antioxidative activity of the extract, the anthocyanin-rich fraction (AF) was determined by 1,1-diphenyl-2-picrylhydrazyl radical and ferric-reducing ability of plasma along with resveratrol as a reference. The immunomodulation properties were assessed in lipopolysaccharide (LPS)-stimulated human monocytes mono mac 6. The isolated AF, containing six different anthocyanins, exhibited a stronger antioxidative capacity compared to resveratrol. Resveratrol enhanced tumor necrosis factor-alpha and reduced interleukin-10 (IL-10) production by LPS, whereas AF only had a slight effect in reducing IL-10. These results demonstrated that there was no major relationship between the antioxidative effect and immunomodulation capacities of AF and resveratrol. The immunomodulatory activity of the extract is associated with bioactive compounds in Aronia other than its anthocyanins.

    KW - anthocyanins

    KW - anti-inflammatory

    KW - antioxidative

    KW - Aronia

    KW - resveratrol

    KW - anthocyanins

    KW - anti-inflammatory

    KW - antioxidative

    KW - Aronia

    KW - resveratrol

    U2 - 10.1089/jmf.2012.0151

    DO - 10.1089/jmf.2012.0151

    M3 - Journal article

    VL - 16

    SP - 334

    EP - 342

    JO - Journal of Medicinal Food

    JF - Journal of Medicinal Food

    SN - 1096-620X

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    ER -