The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions

Lawrence Gilbert, Kim Rewitz

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskning

    Resumé

    The Halloween genes of Drosophila melanogaster were first described in the 1980s using cytogenetic methodology. During the past several years the genes have been cloned, expressed and the gene products have been characterized as cytochrome P450 enzymes (CYPs) and four have been functionalized as mediating the final steps in the biosynthesis of the arthropod molting hormone, 20-hydroxyecdysone (20E). A fifth has now been studied in detail and shown to be required for ecdysteroidogenesis but its exact function has yet to be elucidated. Since both insects and crustaceans utilize 20E as their principal molting hormone we have examined by BLAST search the genome of Daphnia and demonstrated the existence of Halloween gene orthologs in this crustacean, indicating that these genes play an identical role in this class as they do in insects. Further examination of the data bases representing Lepidoptera, Coleoptera, Hymenoptera and other Diptera allowed the development of a phylogenetic scheme for this gene family and suggests that the Halloween genes and vertebrate steroidogenic P450s originated from common ancestors that were perhaps destined for steroidogenesis, and arose before the deuterostome-arthropod split.
    OriginalsprogEngelsk
    TitelThe Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions
    Antal sider38
    ForlagSpringer Science+Business Media
    Publikationsdato2009
    Sider231
    Kapitel269
    StatusUdgivet - 2009

    Citer dette

    Gilbert, L., & Rewitz, K. (2009). The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. I The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions (s. 231). Springer Science+Business Media.
    Gilbert, Lawrence ; Rewitz, Kim. / The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. Springer Science+Business Media, 2009. s. 231
    @inbook{c28ade1cf38b40f6b7bb1da1bb16c9ba,
    title = "The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions",
    abstract = "The Halloween genes of Drosophila melanogaster were first described in the 1980s using cytogenetic methodology. During the past several years the genes have been cloned, expressed and the gene products have been characterized as cytochrome P450 enzymes (CYPs) and four have been functionalized as mediating the final steps in the biosynthesis of the arthropod molting hormone, 20-hydroxyecdysone (20E). A fifth has now been studied in detail and shown to be required for ecdysteroidogenesis but its exact function has yet to be elucidated. Since both insects and crustaceans utilize 20E as their principal molting hormone we have examined by BLAST search the genome of Daphnia and demonstrated the existence of Halloween gene orthologs in this crustacean, indicating that these genes play an identical role in this class as they do in insects. Further examination of the data bases representing Lepidoptera, Coleoptera, Hymenoptera and other Diptera allowed the development of a phylogenetic scheme for this gene family and suggests that the Halloween genes and vertebrate steroidogenic P450s originated from common ancestors that were perhaps destined for steroidogenesis, and arose before the deuterostome-arthropod split.",
    author = "Lawrence Gilbert and Kim Rewitz",
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    language = "English",
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    booktitle = "The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions",
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    Gilbert, L & Rewitz, K 2009, The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. i The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. Springer Science+Business Media, s. 231.

    The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. / Gilbert, Lawrence ; Rewitz, Kim.

    The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. Springer Science+Business Media, 2009. s. 231.

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskning

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    N2 - The Halloween genes of Drosophila melanogaster were first described in the 1980s using cytogenetic methodology. During the past several years the genes have been cloned, expressed and the gene products have been characterized as cytochrome P450 enzymes (CYPs) and four have been functionalized as mediating the final steps in the biosynthesis of the arthropod molting hormone, 20-hydroxyecdysone (20E). A fifth has now been studied in detail and shown to be required for ecdysteroidogenesis but its exact function has yet to be elucidated. Since both insects and crustaceans utilize 20E as their principal molting hormone we have examined by BLAST search the genome of Daphnia and demonstrated the existence of Halloween gene orthologs in this crustacean, indicating that these genes play an identical role in this class as they do in insects. Further examination of the data bases representing Lepidoptera, Coleoptera, Hymenoptera and other Diptera allowed the development of a phylogenetic scheme for this gene family and suggests that the Halloween genes and vertebrate steroidogenic P450s originated from common ancestors that were perhaps destined for steroidogenesis, and arose before the deuterostome-arthropod split.

    AB - The Halloween genes of Drosophila melanogaster were first described in the 1980s using cytogenetic methodology. During the past several years the genes have been cloned, expressed and the gene products have been characterized as cytochrome P450 enzymes (CYPs) and four have been functionalized as mediating the final steps in the biosynthesis of the arthropod molting hormone, 20-hydroxyecdysone (20E). A fifth has now been studied in detail and shown to be required for ecdysteroidogenesis but its exact function has yet to be elucidated. Since both insects and crustaceans utilize 20E as their principal molting hormone we have examined by BLAST search the genome of Daphnia and demonstrated the existence of Halloween gene orthologs in this crustacean, indicating that these genes play an identical role in this class as they do in insects. Further examination of the data bases representing Lepidoptera, Coleoptera, Hymenoptera and other Diptera allowed the development of a phylogenetic scheme for this gene family and suggests that the Halloween genes and vertebrate steroidogenic P450s originated from common ancestors that were perhaps destined for steroidogenesis, and arose before the deuterostome-arthropod split.

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    Gilbert L, Rewitz K. The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. I The Function and Evolution of the Halloween Genes; the Pathway to the Arthropod Molting Hormone. In Ecdysone, Structures and Functions. Springer Science+Business Media. 2009. s. 231