The Donders model of the circulation in normo- and pathophysiology

Gerrit J. Noordergraaf, Johnny T. Ottesen, Wil J.P.M. Kortsmit, Wil H.A. Schilders, Gert J. Scheffer, Abraham Noordergraaf

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Udgivelsesdato: juni
    OriginalsprogEngelsk
    TidsskriftCardiovascular Engineering - an International Journal
    Vol/bind6
    Udgave nummer2
    Sider (fra-til)51-70
    Antal sider19
    ISSN1567-8822
    DOI
    StatusUdgivet - 2006

    Citer dette

    Noordergraaf, G. J., Ottesen, J. T., Kortsmit, W. J. P. M., Schilders, W. H. A., Scheffer, G. J., & Noordergraaf, A. (2006). The Donders model of the circulation in normo- and pathophysiology. Cardiovascular Engineering - an International Journal, 6(2), 51-70. https://doi.org/10.1007/s10558-006-9004-6
    Noordergraaf, Gerrit J. ; Ottesen, Johnny T. ; Kortsmit, Wil J.P.M. ; Schilders, Wil H.A. ; Scheffer, Gert J. ; Noordergraaf, Abraham. / The Donders model of the circulation in normo- and pathophysiology. I: Cardiovascular Engineering - an International Journal. 2006 ; Bind 6, Nr. 2. s. 51-70.
    @article{4a068e20d2ec11db9c7c000ea68e967b,
    title = "The Donders model of the circulation in normo- and pathophysiology",
    abstract = "A model of the closed human cardiovascular loop is developed. This model, using one set of 88 equations, allows variations from normal resting conditions to exercise, as well as to the extreme condition of a circulation following cardiac arrest. The principal purpose of the model is to evaluate the continuum of physiological conditions to cardiopulmonary resuscitation effects within the circulation.   Within the model, Harvey's view of the circulation has been broadened to include impedance-defined flow as a unifying concept. The cardiac function curve, the relation between ventricular filling and output, changes during exercise. First, it rotates counterclockwise and stretches along the output axis, second, it shifts along the filling axis. The first is induced by sympathetic control, the second by respiratory control. The model shows that depth of respiration, sympathetic stimulation of cardiac contractile properties and baroreceptor activity can exert powerful influences on the increase in cardiac output, while heart and respiratory rate increases tend to exert an inhibiting influence. Impedance-defined flow encompasses both positive and negative effects.The model demonstrates the limitations to cardiopulmonary resuscitation caused by external force applied to intrathoracic structures, with effective cardiac output being limited by collapse and sloshing. It demonstrates that the clinical inclination to apply high pressures may be unjustified.",
    keywords = "Cardiovascular system modeling, equations, impedance-defined flow, physiology, cardiopulmonary resuscitation (cpr), circulation",
    author = "Noordergraaf, {Gerrit J.} and Ottesen, {Johnny T.} and Kortsmit, {Wil J.P.M.} and Schilders, {Wil H.A.} and Scheffer, {Gert J.} and Abraham Noordergraaf",
    year = "2006",
    doi = "10.1007/s10558-006-9004-6",
    language = "English",
    volume = "6",
    pages = "51--70",
    journal = "Cardiovascular Engineering",
    issn = "1567-8822",
    publisher = "Springer New York LLC",
    number = "2",

    }

    Noordergraaf, GJ, Ottesen, JT, Kortsmit, WJPM, Schilders, WHA, Scheffer, GJ & Noordergraaf, A 2006, 'The Donders model of the circulation in normo- and pathophysiology', Cardiovascular Engineering - an International Journal, bind 6, nr. 2, s. 51-70. https://doi.org/10.1007/s10558-006-9004-6

    The Donders model of the circulation in normo- and pathophysiology. / Noordergraaf, Gerrit J.; Ottesen, Johnny T.; Kortsmit, Wil J.P.M.; Schilders, Wil H.A.; Scheffer, Gert J.; Noordergraaf, Abraham.

    I: Cardiovascular Engineering - an International Journal, Bind 6, Nr. 2, 2006, s. 51-70.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - The Donders model of the circulation in normo- and pathophysiology

    AU - Noordergraaf, Gerrit J.

    AU - Ottesen, Johnny T.

    AU - Kortsmit, Wil J.P.M.

    AU - Schilders, Wil H.A.

    AU - Scheffer, Gert J.

    AU - Noordergraaf, Abraham

    PY - 2006

    Y1 - 2006

    N2 - A model of the closed human cardiovascular loop is developed. This model, using one set of 88 equations, allows variations from normal resting conditions to exercise, as well as to the extreme condition of a circulation following cardiac arrest. The principal purpose of the model is to evaluate the continuum of physiological conditions to cardiopulmonary resuscitation effects within the circulation.   Within the model, Harvey's view of the circulation has been broadened to include impedance-defined flow as a unifying concept. The cardiac function curve, the relation between ventricular filling and output, changes during exercise. First, it rotates counterclockwise and stretches along the output axis, second, it shifts along the filling axis. The first is induced by sympathetic control, the second by respiratory control. The model shows that depth of respiration, sympathetic stimulation of cardiac contractile properties and baroreceptor activity can exert powerful influences on the increase in cardiac output, while heart and respiratory rate increases tend to exert an inhibiting influence. Impedance-defined flow encompasses both positive and negative effects.The model demonstrates the limitations to cardiopulmonary resuscitation caused by external force applied to intrathoracic structures, with effective cardiac output being limited by collapse and sloshing. It demonstrates that the clinical inclination to apply high pressures may be unjustified.

    AB - A model of the closed human cardiovascular loop is developed. This model, using one set of 88 equations, allows variations from normal resting conditions to exercise, as well as to the extreme condition of a circulation following cardiac arrest. The principal purpose of the model is to evaluate the continuum of physiological conditions to cardiopulmonary resuscitation effects within the circulation.   Within the model, Harvey's view of the circulation has been broadened to include impedance-defined flow as a unifying concept. The cardiac function curve, the relation between ventricular filling and output, changes during exercise. First, it rotates counterclockwise and stretches along the output axis, second, it shifts along the filling axis. The first is induced by sympathetic control, the second by respiratory control. The model shows that depth of respiration, sympathetic stimulation of cardiac contractile properties and baroreceptor activity can exert powerful influences on the increase in cardiac output, while heart and respiratory rate increases tend to exert an inhibiting influence. Impedance-defined flow encompasses both positive and negative effects.The model demonstrates the limitations to cardiopulmonary resuscitation caused by external force applied to intrathoracic structures, with effective cardiac output being limited by collapse and sloshing. It demonstrates that the clinical inclination to apply high pressures may be unjustified.

    KW - Cardiovascular system modeling

    KW - equations

    KW - impedance-defined flow

    KW - physiology

    KW - cardiopulmonary resuscitation (cpr)

    KW - circulation

    U2 - 10.1007/s10558-006-9004-6

    DO - 10.1007/s10558-006-9004-6

    M3 - Journal article

    VL - 6

    SP - 51

    EP - 70

    JO - Cardiovascular Engineering

    JF - Cardiovascular Engineering

    SN - 1567-8822

    IS - 2

    ER -