The Applicability of a Short-term Test for Detection of Modifying Effects of Dietary Factors in Rodent Colon Carcinogenesis

Eva Kristiansen

    Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

    Abstract

    The present studies were initiated to develop a short-term
    rodent model to assess the influence of different dietary
    components on the development of colon cancer.
    Diets with different dietary components, i.e. dietary fibre, fat,
    sucrose, and starches were tested in male rats initiated with
    DMH-2HCl or AOM for their modulating effect on the
    development of aberrant crypt foci (ACF). Furthermore the
    heterocyclic amines IQ and PhIP were introduced in the assay
    as inducers of ACF in mice and rats and their role in colon
    carcinogenesis in mice was investigated.
    ACF were found to be induced in rodent colon by the colon
    carcinogens DMH-2HC1, AOM, IQ, and PhIP and it was
    shown that the incidence of the induced ACF could be
    modulated by dietary components such as sucrose, dietary
    fibre, and starch.
    OriginalsprogEngelsk
    ForlagDanish Veterinary and Food Administration
    Antal sider101
    ISBN (Trykt)87-601-2005-3
    StatusUdgivet - 1997

    Emneord

    • Aberrant crypt foci
    • ACF
    • colcn cancer
    • dietary modulators
    • DMH-2HC1
    • AOM
    • IQ
    • PhIP
    • rat
    • mice

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