Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice

Håvard Jenssen, Andrey Shestakov, Robert E. W Hancock, Inger Nordström, Kristina Eriksson

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

    Abstract

    We have evaluated the potential of four synthetic peptides (denoted HH-2, 1002, 1006, 1018) with a distant relationship to the host defense peptide bovine bactenecin dodecapeptide for their ability to prevent genital infections with herpes simplex virus type 2 (HSV-2) in mice. All four peptides showed antiviral properties in vitro and reduced HSV-2 infection of Vero cells in a dose-dependent manner. Detailed analysis showed that the peptides were able to interfere with both viral attachment and entry, but not with replication post-entry, and were effective antivirals also when HSV-2 was introduced in human semen. Two of the peptides proved especially effective in reducing HSV-2 infection also in vivo. When admixed with virus prior to inoculation, both HH-2 and 1018 reduced viral replication and disease development in a genital model of HSV-2 infection in mice, and also when using very high infectious doses of HSV-2. These data show that peptides HH-2 and 1018 have antiviral properties and can be used to prevent genital herpes infection in mice. (C) 2013 Elsevier B.V. All rights reserved.
    OriginalsprogEngelsk
    TidsskriftAntiviral Research
    Vol/bind100
    Udgave nummer2
    Sider (fra-til)455-459
    ISSN0166-3542
    DOI
    StatusUdgivet - 2013

    Emneord

    • HSV-2
    • antimicrobial peptides
    • bovine bactenecin
    • syntethic analogues
    • genital herpes

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