Lactones and lactams 4–6 were synthesized from a series of acyclic dienes 1–3 via ring-closing olefin metathesis, as shown in equation 1. The geometry of the resulting double bond was determined, and the EIZ ratios compared to values from molecular mechanics calculations.
Goldring, W. P. D., Hodder, A. S., & Weiler, L. (1998). Synthesis of macrocyclic lactams and lactones via ring-closing olefin metathesis. Tetrahedron Letters, 39(28), 4955-4958. https://doi.org/10.1016/S0040-4039(98)00966-6