Staphylococcus aureus colonization in atopic eczema and its association with filaggrin gene mutations

Maja-Lisa Clausen*, S. M. Edslev, P. S. Andersen, K. Clemmensen, K. A. Krogfelt, T. Agner

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Background: Atopic dermatitis (AD) is a prevalent disease with significant impact on physical health and quality of life. Staphylococcus aureus has been directly correlated to disease severity, and may also be a contributing causal factor in the pathogenesis of AD. Objectives: The primary aim was to assess differences in S. aureus colonization in patients with AD with and without filaggrin gene mutations. The secondary aim was to assess disease severity in relation to S. aureus colonization. Exploratory analyses were performed to investigate S. aureus genetic lineages in relation to filaggrin gene (FLG) mutations and disease severity. Methods: Adult patients with AD (n = 101) were included in the study. Bacterial swabs were taken from lesional skin, nonlesional skin and the nose. Swabs
TidsskriftBritish Journal of Dermatology
Udgave nummer5
Sider (fra-til)1394-1400
Antal sider7
StatusUdgivet - nov. 2017
Udgivet eksterntJa

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