Solidification to improve the biopharmaceutical performance of SEDDS

Opportunities and challenges

Paul Joyce, Tahnee J Dening, Tahlia R Meola, Hayley B Schultz, René Holm, Nicky Thomas, Clive A. Prestidge

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the promising biopharmaceutical benefits of liquid lipid formulations has not translated into widespread commercial success, due to their susceptibility to long term storage and in vivo precipitation issues. One strategy that has emerged to overcome such limitations, is to combine the solubilisation and dissolution enhancing properties of lipids with the stabilising effects of solid carrier materials. The development of intelligent hybrid drug formulations has presented new opportunities to harness the potential of emulsified lipids in optimising oral bioavailability for lipophilic therapeutics. Specific emphasis of this review is placed on the impact of solidification approaches and excipients on the biopharmaceutical performance of self-emulsifying lipids, with findings highlighting the key design considerations that should be implemented when developing hybrid lipid-based formulations.
OriginalsprogEngelsk
TidsskriftAdvanced Drug Delivery Reviews
Vol/bind142
Sider (fra-til)102-117
ISSN0169-409X
DOI
StatusUdgivet - 2019

Citer dette

Joyce, P., Dening, T. J., Meola, T. R., Schultz, H. B., Holm, R., Thomas, N., & Prestidge, C. A. (2019). Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges. Advanced Drug Delivery Reviews, 142, 102-117. https://doi.org/10.1016/j.addr.2018.11.006