Role of capsule in Klebsiella pneumoniae virulence: lack of correlation between in vitro and in vivo studies

Carsten Struve, Karen Angeliki Krogfelt

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

In vitro and in vivo models were used to investigate the role of capsule on the virulence of Klebsiella pneumoniae. We showed that capsule expression reduces dramatically the ability of the K. pneumoniae to bind to epithelial cells when compared to its non-capsulated variant. The presence/absence of capsule had no effect on the colonization of the gastrointestinal tract, while in the urinary tract we established that capsule is an important virulence factor. Our study demonstrates the caution needed when extrapolating from results of in vitro studies and emphasizes the necessity of in vivo models in studies of bacterial virulence.
OriginalsprogUdefineret/Ukendt
TidsskriftFEMS Microbiology Letters
Vol/bind218
Udgave nummer1
Sider (fra-til)149-154
Antal sider6
ISSN0378-1097
StatusUdgivet - 2003
Udgivet eksterntJa

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