Role of capsule in Klebsiella pneumoniae virulence: lack of correlation between in vitro and in vivo studies

Carsten Struve, Karen Angeliki Krogfelt

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


In vitro and in vivo models were used to investigate the role of capsule on the virulence of Klebsiella pneumoniae. We showed that capsule expression reduces dramatically the ability of the K. pneumoniae to bind to epithelial cells when compared to its non-capsulated variant. The presence/absence of capsule had no effect on the colonization of the gastrointestinal tract, while in the urinary tract we established that capsule is an important virulence factor. Our study demonstrates the caution needed when extrapolating from results of in vitro studies and emphasizes the necessity of in vivo models in studies of bacterial virulence.
TidsskriftFEMS Microbiology Letters
Udgave nummer1
Sider (fra-til)149-154
Antal sider6
StatusUdgivet - 2003
Udgivet eksterntJa

Citer dette