Resveratrol

    Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

    Resumé

    Testing the biological activities of a dietary compound like resveratrol presents various challenges, which are highlighted in this commentary, with some suggested direction for future research, focusing on five challenges: (1) many different cellular effects are observed for resveratrol, but it is not known whether they arise from one point of action (or a few) or whether resveratrol is non-specific in its action; (2) the health-promotion effect of dietary resveratrol is likely a combinatory effect of various bioactive components in the mixture (diet); (3) the known cell biological response to resveratrol is presently based on exposure to short-term high levels, and better in vitro analyses have to be developed; (4) the actual level of resveratrol and resveratrol metabolites present in vitro and in vivo during experiments may be over- and underestimated, respectively, because resveratrol is not very soluble in water; and (5) only a few small clinical studies have been published to date, focusing on the therapeutic effects of resveratrol. Further, clinical trials addressing the disease-preventive effects are especially challenging.
    OriginalsprogEngelsk
    TidsskriftNew York Academy of Sciences. Annals
    Vol/bind1348
    Udgave nummer1
    Sider (fra-til)161-170
    ISSN0077-8923
    DOI
    StatusUdgivet - 28 aug. 2015

    Emneord

    • Resveratrol
    • combinatory effect
    • clinical trial
    • biological targets

    Citer dette

    Vang, Ole. / Resveratrol. I: New York Academy of Sciences. Annals. 2015 ; Bind 1348, Nr. 1. s. 161-170.
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    title = "Resveratrol",
    abstract = "Testing the biological activities of a dietary compound like resveratrol presents various challenges, which are highlighted in this commentary, with some suggested direction for future research, focusing on five challenges: (1) many different cellular effects are observed for resveratrol, but it is not known whether they arise from one point of action (or a few) or whether resveratrol is non-specific in its action; (2) the health-promotion effect of dietary resveratrol is likely a combinatory effect of various bioactive components in the mixture (diet); (3) the known cell biological response to resveratrol is presently based on exposure to short-term high levels, and better in vitro analyses have to be developed; (4) the actual level of resveratrol and resveratrol metabolites present in vitro and in vivo during experiments may be over- and underestimated, respectively, because resveratrol is not very soluble in water; and (5) only a few small clinical studies have been published to date, focusing on the therapeutic effects of resveratrol. Further, clinical trials addressing the disease-preventive effects are especially challenging",
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    author = "Ole Vang",
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    Resveratrol. / Vang, Ole.

    I: New York Academy of Sciences. Annals, Bind 1348, Nr. 1, 28.08.2015, s. 161-170.

    Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

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    AB - Testing the biological activities of a dietary compound like resveratrol presents various challenges, which are highlighted in this commentary, with some suggested direction for future research, focusing on five challenges: (1) many different cellular effects are observed for resveratrol, but it is not known whether they arise from one point of action (or a few) or whether resveratrol is non-specific in its action; (2) the health-promotion effect of dietary resveratrol is likely a combinatory effect of various bioactive components in the mixture (diet); (3) the known cell biological response to resveratrol is presently based on exposure to short-term high levels, and better in vitro analyses have to be developed; (4) the actual level of resveratrol and resveratrol metabolites present in vitro and in vivo during experiments may be over- and underestimated, respectively, because resveratrol is not very soluble in water; and (5) only a few small clinical studies have been published to date, focusing on the therapeutic effects of resveratrol. Further, clinical trials addressing the disease-preventive effects are especially challenging

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