Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review


    Testing the biological activities of a dietary compound like resveratrol presents various challenges, which are highlighted in this commentary, with some suggested direction for future research, focusing on five challenges: (1) many different cellular effects are observed for resveratrol, but it is not known whether they arise from one point of action (or a few) or whether resveratrol is non-specific in its action; (2) the health-promotion effect of dietary resveratrol is likely a combinatory effect of various bioactive components in the mixture (diet); (3) the known cell biological response to resveratrol is presently based on exposure to short-term high levels, and better in vitro analyses have to be developed; (4) the actual level of resveratrol and resveratrol metabolites present in vitro and in vivo during experiments may be over- and underestimated, respectively, because resveratrol is not very soluble in water; and (5) only a few small clinical studies have been published to date, focusing on the therapeutic effects of resveratrol. Further, clinical trials addressing the disease-preventive effects are especially challenging.
    TidsskriftNew York Academy of Sciences. Annals
    Udgave nummer1
    Sider (fra-til)161-170
    StatusUdgivet - 28 aug. 2015


    • Resveratrol
    • combinatory effect
    • clinical trial
    • biological targets

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