Projekter pr. år
Abstract
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections (RTIs) in young children. High-quality country-specific estimates of bed days and length of stay (LOS) show the population burden of RSV-RTI on secondary care services and the burden among patients, and can be used to inform RSV immunization implementation decisions. METHODS: We estimated the hospital burden of RSV-associated RTI (RSV-RTI) in children under 5 years in 7 European countries (Finland, Denmark, Norway, Scotland, England, the Netherlands, and Italy) using routinely collected hospital databases during 2001-2018. We described RSV-RTI admission rates during the first year of life by birth month and assessed their correlation with RSV seasonality in 5 of the countries (except for England and Italy). We estimated average annual numbers and rates of bed days for RSV-RTI and other-pathogen RTI, as well as the hospital LOS. RESULTS: We found that infants born 2 months before the peak month of RSV epidemics more frequently had the highest RSV-RTI hospital admission rate. RSV-RTI hospital episodes accounted for 9.9-21.2 bed days per 1000 children aged <5 years annually, with the median (interquartile range) LOS ranging from 2 days (0.5-4 days) to 4 days (2-6 days) between countries. Between 70% and 89% of these bed days were in infants aged <1 year, representing 40.3 (95% confidence interval [CI], 40.1-40.4) to 91.2 (95% CI, 90.6-91.8) bed days per 1000 infants annually. The number of bed days for RSV-RTI was higher than that for RTIs associated with other pathogens in infants aged <1 year, especially in those <6 months. CONCLUSIONS: RSV disease prevention therapies (monoclonal antibodies and maternal vaccines) for infants could help prevent a substantial number of bed days due to RSV-RTI. "High-risk" birth months should be considered when developing RSV immunization schedules. Variation in LOS between countries might reflect differences in hospital care practices.
Originalsprog | Engelsk |
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Tidsskrift | The Journal of Infectious Diseases |
Vol/bind | 226 |
Udgave nummer | 1 |
Sider (fra-til) | S22-S28 |
ISSN | 0022-1899 |
DOI | |
Status | Udgivet - 12 aug. 2022 |
Bibliografisk note
This article was found as a 'Free version' at the Publisher on January 2, 2023. If the access closes, please contact [email protected]Emneord
- bed days
- birth month
- Europe
- hospital admission
- respiratory syncytial virus
Projekter
- 1 Afsluttet
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RESCEU: RESCEU - REspiratory Syncytial virus Consortium in EUrope
Wijhe, M. V. (Projektdeltager)
01/01/2018 → 31/12/2020
Projekter: Projekt › Forskning