Resistance to Antimicrobial Chemotherapy

A Prescription for Research and Action

B. R.q Levin, R. Anita, E. Berllner, P. Bloland, S. Bonhoeffer, M. Cohen, T. Derouin, P. I. Fields, H. Jafari, D. Jernigan, M. Lipsitch, J. E. Mcgowan, M. Nowak, T. Porco, P. Sykora, Lone Simonsen, J. Spitznagel, R. Tauxe, F. Tenover

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Resumé

The growing problem of resistance to antimicrobial chemotherapy was discussed by participants at the February 1995 workshop at Emory University on population biology, evolution, and control of infectious diseases. They discussed the nature and source of this problem and identified areas of research in which information is lacking for the development of programs to control of the emergence and spread of resistant bacteria. Particular attention was given to theoretical (mathematical modeling) and empirical studies of the within and between-host population biology (epidemiology) and the evolution of microbial resistance to chemotherapeutic agents. Suggestions were made about the kinds of models and data needed, and the procedures that could be employed to stem the ascent and dissemination of resistant bacteria. This article summarizes the observations and recommendations made at the 1995 meeting and in the correspondence between participants that followed. It concludes with an update on the theoretical and empirical research on the between- and within-host population biology and evolution of resistance to antimicrobial chemotherapy most of which has been done since that meeting.
OriginalsprogEngelsk
TidsskriftAmerican Journal of the Medical Sciences
Vol/bind315
Udgave nummer2
Antal sider8
ISSN0002-9629
DOI
StatusUdgivet - 1998
Udgivet eksterntJa

Citer dette

Levin, B. R. Q., Anita, R., Berllner, E., Bloland, P., Bonhoeffer, S., Cohen, M., ... Tenover, F. (1998). Resistance to Antimicrobial Chemotherapy: A Prescription for Research and Action. American Journal of the Medical Sciences, 315(2). https://doi.org/10.1016/S0002-9629(15)40282-4
Levin, B. R.q ; Anita, R. ; Berllner, E. ; Bloland, P. ; Bonhoeffer, S. ; Cohen, M. ; Derouin, T. ; Fields, P. I. ; Jafari, H. ; Jernigan, D. ; Lipsitch, M. ; Mcgowan, J. E. ; Nowak, M. ; Porco, T. ; Sykora, P. ; Simonsen, Lone ; Spitznagel, J. ; Tauxe, R. ; Tenover, F. / Resistance to Antimicrobial Chemotherapy : A Prescription for Research and Action. I: American Journal of the Medical Sciences. 1998 ; Bind 315, Nr. 2.
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abstract = "The growing problem of resistance to antimicrobial chemotherapy was discussed by participants at the February 1995 workshop at Emory University on population biology, evolution, and control of infectious diseases. They discussed the nature and source of this problem and identified areas of research in which information is lacking for the development of programs to control of the emergence and spread of resistant bacteria. Particular attention was given to theoretical (mathematical modeling) and empirical studies of the within and between-host population biology (epidemiology) and the evolution of microbial resistance to chemotherapeutic agents. Suggestions were made about the kinds of models and data needed, and the procedures that could be employed to stem the ascent and dissemination of resistant bacteria. This article summarizes the observations and recommendations made at the 1995 meeting and in the correspondence between participants that followed. It concludes with an update on the theoretical and empirical research on the between- and within-host population biology and evolution of resistance to antimicrobial chemotherapy most of which has been done since that meeting.",
author = "Levin, {B. R.q} and R. Anita and E. Berllner and P. Bloland and S. Bonhoeffer and M. Cohen and T. Derouin and Fields, {P. I.} and H. Jafari and D. Jernigan and M. Lipsitch and Mcgowan, {J. E.} and M. Nowak and T. Porco and P. Sykora and Lone Simonsen and J. Spitznagel and R. Tauxe and F. Tenover",
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Levin, BRQ, Anita, R, Berllner, E, Bloland, P, Bonhoeffer, S, Cohen, M, Derouin, T, Fields, PI, Jafari, H, Jernigan, D, Lipsitch, M, Mcgowan, JE, Nowak, M, Porco, T, Sykora, P, Simonsen, L, Spitznagel, J, Tauxe, R & Tenover, F 1998, 'Resistance to Antimicrobial Chemotherapy: A Prescription for Research and Action', American Journal of the Medical Sciences, bind 315, nr. 2. https://doi.org/10.1016/S0002-9629(15)40282-4

Resistance to Antimicrobial Chemotherapy : A Prescription for Research and Action. / Levin, B. R.q; Anita, R.; Berllner, E.; Bloland, P.; Bonhoeffer, S.; Cohen, M.; Derouin, T.; Fields, P. I.; Jafari, H. ; Jernigan, D.; Lipsitch, M.; Mcgowan, J. E.; Nowak, M.; Porco, T.; Sykora, P.; Simonsen, Lone; Spitznagel, J.; Tauxe, R.; Tenover, F.

I: American Journal of the Medical Sciences, Bind 315, Nr. 2, 1998.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Resistance to Antimicrobial Chemotherapy

T2 - A Prescription for Research and Action

AU - Levin, B. R.q

AU - Anita, R.

AU - Berllner, E.

AU - Bloland, P.

AU - Bonhoeffer, S.

AU - Cohen, M.

AU - Derouin, T.

AU - Fields, P. I.

AU - Jafari, H.

AU - Jernigan, D.

AU - Lipsitch, M.

AU - Mcgowan, J. E.

AU - Nowak, M.

AU - Porco, T.

AU - Sykora, P.

AU - Simonsen, Lone

AU - Spitznagel, J.

AU - Tauxe, R.

AU - Tenover, F.

PY - 1998

Y1 - 1998

N2 - The growing problem of resistance to antimicrobial chemotherapy was discussed by participants at the February 1995 workshop at Emory University on population biology, evolution, and control of infectious diseases. They discussed the nature and source of this problem and identified areas of research in which information is lacking for the development of programs to control of the emergence and spread of resistant bacteria. Particular attention was given to theoretical (mathematical modeling) and empirical studies of the within and between-host population biology (epidemiology) and the evolution of microbial resistance to chemotherapeutic agents. Suggestions were made about the kinds of models and data needed, and the procedures that could be employed to stem the ascent and dissemination of resistant bacteria. This article summarizes the observations and recommendations made at the 1995 meeting and in the correspondence between participants that followed. It concludes with an update on the theoretical and empirical research on the between- and within-host population biology and evolution of resistance to antimicrobial chemotherapy most of which has been done since that meeting.

AB - The growing problem of resistance to antimicrobial chemotherapy was discussed by participants at the February 1995 workshop at Emory University on population biology, evolution, and control of infectious diseases. They discussed the nature and source of this problem and identified areas of research in which information is lacking for the development of programs to control of the emergence and spread of resistant bacteria. Particular attention was given to theoretical (mathematical modeling) and empirical studies of the within and between-host population biology (epidemiology) and the evolution of microbial resistance to chemotherapeutic agents. Suggestions were made about the kinds of models and data needed, and the procedures that could be employed to stem the ascent and dissemination of resistant bacteria. This article summarizes the observations and recommendations made at the 1995 meeting and in the correspondence between participants that followed. It concludes with an update on the theoretical and empirical research on the between- and within-host population biology and evolution of resistance to antimicrobial chemotherapy most of which has been done since that meeting.

U2 - 10.1016/S0002-9629(15)40282-4

DO - 10.1016/S0002-9629(15)40282-4

M3 - Journal article

VL - 315

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 2

ER -