TY - JOUR
T1 - Residential exposure to transportation noise and risk of incident atrial fibrillation
T2 - a pooled study of 11 prospective Nordic cohorts
AU - Thacher, Jesse D.
AU - Roswall, Nina
AU - Ögren, Mikael
AU - Pyko, Andrei
AU - Åkesson, Agneta
AU - Oudin, Anna
AU - Rosengren, Annika
AU - Poulsen, Aslak H.
AU - Eriksson, Charlotta
AU - Segersson, David
AU - Rizzuto, Debora
AU - Helte, Emilie
AU - Andersson, Eva M.
AU - Aasvang, Gunn Marit
AU - Engström, Gunnar
AU - Gudjonsdottir, Hrafnhildur
AU - Selander, Jenny
AU - Christensen, Jesper H.
AU - Brandt, Jørgen
AU - Leander, Karin
AU - Overvad, Kim
AU - Mattisson, Kristoffer
AU - Eneroth, Kristina
AU - Stucki, Lara
AU - Barregard, Lars
AU - Stockfelt, Leo
AU - Albin, Maria
AU - Simonsen, Mette K.
AU - Raaschou-Nielsen, Ole
AU - Jousilahti, Pekka
AU - Tiittanen, Pekka
AU - Ljungman, Petter L.S.
AU - Jensen, Steen S.
AU - Gustafsson, Susanna
AU - Yli-Tuomi, Tarja
AU - Cole-Hunter, Thomas
AU - Lanki, Timo
AU - Lim, Youn Hee
AU - Andersen, Zorana J.
AU - Pershagen, Göran
AU - Sørensen, Mette
PY - 2024/11
Y1 - 2024/11
N2 - Background: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort. Methods: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (Lden) and AF after adjusting for sociodemographics, lifestyle, and air pollution. Findings: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined. Interpretation: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF. Funding: NordForsk.
AB - Background: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort. Methods: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (Lden) and AF after adjusting for sociodemographics, lifestyle, and air pollution. Findings: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined. Interpretation: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF. Funding: NordForsk.
KW - Air pollution
KW - Aircraft noise
KW - Arrhythmia
KW - Atrial fibrillation
KW - Cardiac
KW - Pooled cohort
KW - Railway noise
KW - Road traffic noise
KW - Air pollution
KW - Aircraft noise
KW - Arrhythmia
KW - Atrial fibrillation
KW - Cardiac
KW - Pooled cohort
KW - Railway noise
KW - Road traffic noise
U2 - 10.1016/j.lanepe.2024.101091
DO - 10.1016/j.lanepe.2024.101091
M3 - Journal article
AN - SCOPUS:85205322497
SN - 2666-7762
VL - 46
JO - The Lancet Regional Health - Europe
JF - The Lancet Regional Health - Europe
M1 - 101091
ER -