Replicate Once Per Cell Cycle

Replication Control of Secondary Chromosomes

Florian Fournes, Marie-Eve Val, Ole Skovgaard, Didier Mazel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Faithful vertical transmission of genetic information, especially of essential core genes, is a prerequisite for bacterial survival. Hence, replication of all the replicons is tightly controlled to ensure that all daughter cells get the same genome copy as their mother cell. Essential core genes are very often carried by the main chromosome. However they can occasionally be found on secondary chromosomes, recently renamed chromids. Chromids have evolved from non-essential megaplasmids, and further acquired essential core genes and a genomic signature closed to that of the main chromosome. All chromids carry a plasmidic replication origin, belonging so far to either the iterons or repABC type. Based on these differences, two categories of chromids have been distinguished. In this review, we focus on the replication initiation controls of these two types of chromids. We show that the sophisticated mechanisms controlling their replication evolved from their plasmid counterparts to allow a timely controlled replication, occurring once per cell cycle.
OriginalsprogEngelsk
Artikelnummer1833
TidsskriftFrontiers in Microbiology
Vol/bind9
Udgave nummer2018
ISSN1664-302X
DOI
StatusUdgivet - 7 aug. 2018

Citer dette

Fournes, Florian ; Val, Marie-Eve ; Skovgaard, Ole ; Mazel, Didier. / Replicate Once Per Cell Cycle : Replication Control of Secondary Chromosomes. I: Frontiers in Microbiology. 2018 ; Bind 9, Nr. 2018.
@article{fb779b9d3d2543fdb091cdb47a189882,
title = "Replicate Once Per Cell Cycle: Replication Control of Secondary Chromosomes",
abstract = "Faithful vertical transmission of genetic information, especially of essential core genes, is a prerequisite for bacterial survival. Hence, replication of all the replicons is tightly controlled to ensure that all daughter cells get the same genome copy as their mother cell. Essential core genes are very often carried by the main chromosome. However they can occasionally be found on secondary chromosomes, recently renamed chromids. Chromids have evolved from non-essential megaplasmids, and further acquired essential core genes and a genomic signature closed to that of the main chromosome. All chromids carry a plasmidic replication origin, belonging so far to either the iterons or repABC type. Based on these differences, two categories of chromids have been distinguished. In this review, we focus on the replication initiation controls of these two types of chromids. We show that the sophisticated mechanisms controlling their replication evolved from their plasmid counterparts to allow a timely controlled replication, occurring once per cell cycle.",
keywords = "megaplasmids, replication initiation, chromids, repABC, iterons",
author = "Florian Fournes and Marie-Eve Val and Ole Skovgaard and Didier Mazel",
year = "2018",
month = "8",
day = "7",
doi = "10.3389/fmicb.2018.01833",
language = "English",
volume = "9",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A.",
number = "2018",

}

Replicate Once Per Cell Cycle : Replication Control of Secondary Chromosomes. / Fournes, Florian; Val, Marie-Eve; Skovgaard, Ole; Mazel, Didier.

I: Frontiers in Microbiology, Bind 9, Nr. 2018, 1833, 07.08.2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Replicate Once Per Cell Cycle

T2 - Replication Control of Secondary Chromosomes

AU - Fournes, Florian

AU - Val, Marie-Eve

AU - Skovgaard, Ole

AU - Mazel, Didier

PY - 2018/8/7

Y1 - 2018/8/7

N2 - Faithful vertical transmission of genetic information, especially of essential core genes, is a prerequisite for bacterial survival. Hence, replication of all the replicons is tightly controlled to ensure that all daughter cells get the same genome copy as their mother cell. Essential core genes are very often carried by the main chromosome. However they can occasionally be found on secondary chromosomes, recently renamed chromids. Chromids have evolved from non-essential megaplasmids, and further acquired essential core genes and a genomic signature closed to that of the main chromosome. All chromids carry a plasmidic replication origin, belonging so far to either the iterons or repABC type. Based on these differences, two categories of chromids have been distinguished. In this review, we focus on the replication initiation controls of these two types of chromids. We show that the sophisticated mechanisms controlling their replication evolved from their plasmid counterparts to allow a timely controlled replication, occurring once per cell cycle.

AB - Faithful vertical transmission of genetic information, especially of essential core genes, is a prerequisite for bacterial survival. Hence, replication of all the replicons is tightly controlled to ensure that all daughter cells get the same genome copy as their mother cell. Essential core genes are very often carried by the main chromosome. However they can occasionally be found on secondary chromosomes, recently renamed chromids. Chromids have evolved from non-essential megaplasmids, and further acquired essential core genes and a genomic signature closed to that of the main chromosome. All chromids carry a plasmidic replication origin, belonging so far to either the iterons or repABC type. Based on these differences, two categories of chromids have been distinguished. In this review, we focus on the replication initiation controls of these two types of chromids. We show that the sophisticated mechanisms controlling their replication evolved from their plasmid counterparts to allow a timely controlled replication, occurring once per cell cycle.

KW - megaplasmids

KW - replication initiation

KW - chromids

KW - repABC

KW - iterons

U2 - 10.3389/fmicb.2018.01833

DO - 10.3389/fmicb.2018.01833

M3 - Journal article

VL - 9

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

IS - 2018

M1 - 1833

ER -