Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

Robin C. Puett; Aslak Harbo Poulsen; Tahir Taj; Matthias Ketzel; Camilla Geels; Jørgen Brandt; Jesper H. Christensen; Mette Sørensen; Nina Roswall; Ulla Hvidtfeldt; Ole Raaschou-Nielsen

doi:10.1038/s41416-020-01058-2

Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

Robin C. Puett^*, Aslak Harbo Poulsen, Tahir Taj, Matthias Ketzel, Camilla Geels, Jørgen Brandt, Jesper H. Christensen, Mette Sørensen, Nina Roswall, Ulla Hvidtfeldt, Ole Raaschou-Nielsen

^*Corresponding author

Institut for Naturvidenskab og Miljø

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Background: Few population-based epidemiological studies of adults have examined the relationship between air pollution and leukaemias. Methods: Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, we examined whether particulate matter (PM_2.5), black carbon (BC), nitrogen dioxide (NO₂) and ozone (O₃) averaged over 1, 5 or 10 years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624 age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for socio-demographic factors, assessed exposure to each pollutant with leukaemias. Results: Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM_2.5 prior to diagnosis (e.g. OR per 10 µg/m³ for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC. Results were driven by participants 70 years and older (OR per 10 µg/m³ for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findings for younger participants. Higher 1-year average PM_2.5 exposures were associated with higher risks for acute myeloid and chronic lymphoblastic leukaemia. Conclusion: Among older adults, higher risk for leukaemia was associated with higher residential PM_2.5 concentrations averaged over 1, 5 and 10 years prior to diagnosis.

Originalsprog	Engelsk
Tidsskrift	British Journal of Cancer
Vol/bind	123
Udgave nummer	12
Sider (fra-til)	1818-1824
Antal sider	7
ISSN	0007-0920
DOI	https://doi.org/10.1038/s41416-020-01058-2
Status	Udgivet - 8 dec. 2020

Bibliografisk note

Funding Information:
Funding information The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir - Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries). The funding source had no involvement in the study design, collection, analysis, interpretation, writing and decision to submit for publication. NORDFORSK is a research funding organisation under the Nordic governments.

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Cancer Research UK.

Link til dokument

10.1038/s41416-020-01058-2

Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish populationForlagets udgivne version, 321 KBLicens: CC BY

Citer dette

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title = "Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population",

abstract = "Background: Few population-based epidemiological studies of adults have examined the relationship between air pollution and leukaemias. Methods: Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, we examined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10 years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624 age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for socio-demographic factors, assessed exposure to each pollutant with leukaemias. Results: Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 prior to diagnosis (e.g. OR per 10 µg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC. Results were driven by participants 70 years and older (OR per 10 µg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findings for younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chronic lymphoblastic leukaemia. Conclusion: Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averaged over 1, 5 and 10 years prior to diagnosis.",

author = "Puett, {Robin C.} and Poulsen, {Aslak Harbo} and Tahir Taj and Matthias Ketzel and Camilla Geels and J{\o}rgen Brandt and Christensen, {Jesper H.} and Mette S{\o}rensen and Nina Roswall and Ulla Hvidtfeldt and Ole Raaschou-Nielsen",

note = "Funding Information: Funding information The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir - Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries). The funding source had no involvement in the study design, collection, analysis, interpretation, writing and decision to submit for publication. NORDFORSK is a research funding organisation under the Nordic governments. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Cancer Research UK.",

year = "2020",

month = dec,

day = "8",

doi = "10.1038/s41416-020-01058-2",

language = "English",

volume = "123",

pages = "1818--1824",

journal = "British Journal of Cancer",

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TY - JOUR

T1 - Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

AU - Puett, Robin C.

AU - Poulsen, Aslak Harbo

AU - Taj, Tahir

AU - Ketzel, Matthias

AU - Geels, Camilla

AU - Brandt, Jørgen

AU - Christensen, Jesper H.

AU - Sørensen, Mette

AU - Roswall, Nina

AU - Hvidtfeldt, Ulla

AU - Raaschou-Nielsen, Ole

N1 - Funding Information: Funding information The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir - Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries). The funding source had no involvement in the study design, collection, analysis, interpretation, writing and decision to submit for publication. NORDFORSK is a research funding organisation under the Nordic governments. Publisher Copyright: © 2020, The Author(s), under exclusive licence to Cancer Research UK.

PY - 2020/12/8

Y1 - 2020/12/8

N2 - Background: Few population-based epidemiological studies of adults have examined the relationship between air pollution and leukaemias. Methods: Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, we examined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10 years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624 age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for socio-demographic factors, assessed exposure to each pollutant with leukaemias. Results: Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 prior to diagnosis (e.g. OR per 10 µg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC. Results were driven by participants 70 years and older (OR per 10 µg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findings for younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chronic lymphoblastic leukaemia. Conclusion: Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averaged over 1, 5 and 10 years prior to diagnosis.

AB - Background: Few population-based epidemiological studies of adults have examined the relationship between air pollution and leukaemias. Methods: Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, we examined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10 years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624 age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for socio-demographic factors, assessed exposure to each pollutant with leukaemias. Results: Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 prior to diagnosis (e.g. OR per 10 µg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC. Results were driven by participants 70 years and older (OR per 10 µg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findings for younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chronic lymphoblastic leukaemia. Conclusion: Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averaged over 1, 5 and 10 years prior to diagnosis.

U2 - 10.1038/s41416-020-01058-2

DO - 10.1038/s41416-020-01058-2

M3 - Journal article

C2 - 32939055

AN - SCOPUS:85091133854

SN - 0007-0920

VL - 123

SP - 1818

EP - 1824

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 12

ER -