Recurrences after intensity modulated radiotherapy for head and neck squamous cell carcinoma more likely to originate from regions with high baseline [18F]-FDG uptake.

Anne Kirkebjerg Due, Ivan Richter Vogelius, Marianne Aznar, Søren M. Bentzen, Anne Kiil Berthelsen, Stine Korreman, Annika Loft, Claus Andrup Kristensen, Lena Specht

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Background and purpose: To analyze the recurrence pattern in relation to target volumes and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54% (95% CI 37–69%) of recurrences originated inside the FDG-positive volume and 96% (95% CI 86–99%) in the high dose region. Recurrence density was significantly higher in the central target volumes (P < 0.0001) and increased with increasing FDG avidity (P = 0.036). Conclusions: The detailed pattern-of-failure data analysis suggests that most recurrences occur in the FDG PET positive areas or the solid tumor
    OriginalsprogEngelsk
    TidsskriftRadiotherapy & Oncology
    Vol/bind111
    Udgave nummer3
    Sider (fra-til)360-365
    ISSN0167-8140
    DOI
    StatusUdgivet - 2014

    Emneord

    • FDG-PET
    • Head and neck cancer
    • Pattern of failure
    • Radiotherapy
    • Recurrence

    Citer dette

    Due, Anne Kirkebjerg ; Vogelius, Ivan Richter ; Aznar, Marianne ; Bentzen, Søren M. ; Berthelsen, Anne Kiil ; Korreman, Stine ; Loft, Annika ; Kristensen, Claus Andrup ; Specht, Lena. / Recurrences after intensity modulated radiotherapy for head and neck squamous cell carcinoma more likely to originate from regions with high baseline [18F]-FDG uptake. I: Radiotherapy & Oncology. 2014 ; Bind 111, Nr. 3. s. 360-365.
    @article{919b5607c6374b28a4051c0d70312eec,
    title = "Recurrences after intensity modulated radiotherapy for head and neck squamous cell carcinoma more likely to originate from regions with high baseline [18F]-FDG uptake.",
    abstract = "Background and purpose: To analyze the recurrence pattern in relation to target volumes and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54{\%} (95{\%} CI 37–69{\%}) of recurrences originated inside the FDG-positive volume and 96{\%} (95{\%} CI 86–99{\%}) in the high dose region. Recurrence density was significantly higher in the central target volumes (P < 0.0001) and increased with increasing FDG avidity (P = 0.036). Conclusions: The detailed pattern-of-failure data analysis suggests that most recurrences occur in the FDG PET positive areas or the solid tumor.",
    keywords = "FDG-PET , Head and neck cancer, Pattern of failure, Radiotherapy, Recurrence, FDG-PET , Head and neck cancer, Pattern of failure, Radiotherapy, Recurrence",
    author = "Due, {Anne Kirkebjerg} and Vogelius, {Ivan Richter} and Marianne Aznar and Bentzen, {S{\o}ren M.} and Berthelsen, {Anne Kiil} and Stine Korreman and Annika Loft and Kristensen, {Claus Andrup} and Lena Specht",
    year = "2014",
    doi = "10.1016/j.radonc.2014.06.001",
    language = "English",
    volume = "111",
    pages = "360--365",
    journal = "Radiotherapy & Oncology",
    issn = "0167-8140",
    publisher = "Elsevier Ireland Ltd",
    number = "3",

    }

    Recurrences after intensity modulated radiotherapy for head and neck squamous cell carcinoma more likely to originate from regions with high baseline [18F]-FDG uptake. / Due, Anne Kirkebjerg; Vogelius, Ivan Richter; Aznar, Marianne; Bentzen, Søren M.; Berthelsen, Anne Kiil; Korreman, Stine; Loft, Annika; Kristensen, Claus Andrup; Specht, Lena.

    I: Radiotherapy & Oncology, Bind 111, Nr. 3, 2014, s. 360-365.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Recurrences after intensity modulated radiotherapy for head and neck squamous cell carcinoma more likely to originate from regions with high baseline [18F]-FDG uptake.

    AU - Due, Anne Kirkebjerg

    AU - Vogelius, Ivan Richter

    AU - Aznar, Marianne

    AU - Bentzen, Søren M.

    AU - Berthelsen, Anne Kiil

    AU - Korreman, Stine

    AU - Loft, Annika

    AU - Kristensen, Claus Andrup

    AU - Specht, Lena

    PY - 2014

    Y1 - 2014

    N2 - Background and purpose: To analyze the recurrence pattern in relation to target volumes and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54% (95% CI 37–69%) of recurrences originated inside the FDG-positive volume and 96% (95% CI 86–99%) in the high dose region. Recurrence density was significantly higher in the central target volumes (P < 0.0001) and increased with increasing FDG avidity (P = 0.036). Conclusions: The detailed pattern-of-failure data analysis suggests that most recurrences occur in the FDG PET positive areas or the solid tumor.

    AB - Background and purpose: To analyze the recurrence pattern in relation to target volumes and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54% (95% CI 37–69%) of recurrences originated inside the FDG-positive volume and 96% (95% CI 86–99%) in the high dose region. Recurrence density was significantly higher in the central target volumes (P < 0.0001) and increased with increasing FDG avidity (P = 0.036). Conclusions: The detailed pattern-of-failure data analysis suggests that most recurrences occur in the FDG PET positive areas or the solid tumor.

    KW - FDG-PET

    KW - Head and neck cancer

    KW - Pattern of failure

    KW - Radiotherapy

    KW - Recurrence

    KW - FDG-PET

    KW - Head and neck cancer

    KW - Pattern of failure

    KW - Radiotherapy

    KW - Recurrence

    U2 - 10.1016/j.radonc.2014.06.001

    DO - 10.1016/j.radonc.2014.06.001

    M3 - Journal article

    VL - 111

    SP - 360

    EP - 365

    JO - Radiotherapy & Oncology

    JF - Radiotherapy & Oncology

    SN - 0167-8140

    IS - 3

    ER -