RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation

Sofie Ceberg, Isabel Gagne, Helen Gustafsson, Jonas Bengtsson Scherman, Stine Korreman, Flemming Kjær-Kristoffersen, Michelle Hilts, Sven ÅJ Bäck

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    The aim of this study was to verify the advanced inhomogeneous dose distribution produced by a volumetric arc therapy technique (RapidArc™) using 3D gel measurements and Monte Carlo (MC) simulations. The TPS (treatment planning system)-calculated dose distribution was compared with gel measurements and MC simulations, thus investigating any discrepancy between the planned dose delivery and the actual delivery. Additionally, the reproducibility of the delivery was investigated using repeated gel measurements. A prostate treatment plan was delivered to a 1.3 liter nPAG gel phantom using one single arc rotation and a target dose of 3.3 Gy. Magnetic resonance imaging of the gel was carried out using a 1.5 T scanner. The MC dose distributions were calculated using the VIMC-Arc code. The relative absorbed dose differences were calculated voxel-by-voxel, within the volume enclosed by the 90% isodose surface (VOI90), for the TPS versus gel and TPS versus MC. The differences between the verification methods, MC versus gel, and between two repeated gel measurements were investigated in the same way. For all volume comparisons, the mean value was within 1% and the standard deviation of the differences was within 2.5% (1SD). A 3D gamma analysis between the dose matrices were carried out using gamma criteria 3%/3 mm and 5%/5 mm (% dose difference and mm distance to agreement) within the volume enclosed by the 50% isodose surface (VOI50) and the 90% isodose surface (VOI90), respectively. All comparisons resulted in very high pass rates. More than 95% of the TPS points were within 3%/3 mm of both the gel measurement and MC simulation, both inside VOI50 and VOI90. Additionally, the repeated gel measurements showed excellent consistency, indicating reproducible delivery. Using MC simulations and gel measurements, this verification study successfully demonstrated that the RapidArc™ plan was both accurately calculated and delivered as planned.
    OriginalsprogEngelsk
    TidsskriftPhysics in Medicine and Biology
    Vol/bind55
    Udgave nummer17
    Sider (fra-til)4885-4898
    ISSN0031-9155
    DOI
    StatusUdgivet - sep. 2010

    Citer dette

    Ceberg, S., Gagne, I., Gustafsson, H., Scherman, J. B., Korreman, S., Kjær-Kristoffersen, F., ... Bäck, S. ÅJ. (2010). RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation. Physics in Medicine and Biology, 55(17), 4885-4898. https://doi.org/10.1088/0031-9155/55/17/001
    Ceberg, Sofie ; Gagne, Isabel ; Gustafsson, Helen ; Scherman, Jonas Bengtsson ; Korreman, Stine ; Kjær-Kristoffersen, Flemming ; Hilts, Michelle ; Bäck, Sven ÅJ. / RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation. I: Physics in Medicine and Biology. 2010 ; Bind 55, Nr. 17. s. 4885-4898.
    @article{c04ecd4a55694d09896c87f838a6ccd2,
    title = "RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation",
    abstract = "The aim of this study was to verify the advanced inhomogeneous dose distribution produced by a volumetric arc therapy technique (RapidArc™) using 3D gel measurements and Monte Carlo (MC) simulations. The TPS (treatment planning system)-calculated dose distribution was compared with gel measurements and MC simulations, thus investigating any discrepancy between the planned dose delivery and the actual delivery. Additionally, the reproducibility of the delivery was investigated using repeated gel measurements. A prostate treatment plan was delivered to a 1.3 liter nPAG gel phantom using one single arc rotation and a target dose of 3.3 Gy. Magnetic resonance imaging of the gel was carried out using a 1.5 T scanner. The MC dose distributions were calculated using the VIMC-Arc code. The relative absorbed dose differences were calculated voxel-by-voxel, within the volume enclosed by the 90{\%} isodose surface (VOI90), for the TPS versus gel and TPS versus MC. The differences between the verification methods, MC versus gel, and between two repeated gel measurements were investigated in the same way. For all volume comparisons, the mean value was within 1{\%} and the standard deviation of the differences was within 2.5{\%} (1SD). A 3D gamma analysis between the dose matrices were carried out using gamma criteria 3{\%}/3 mm and 5{\%}/5 mm ({\%} dose difference and mm distance to agreement) within the volume enclosed by the 50{\%} isodose surface (VOI50) and the 90{\%} isodose surface (VOI90), respectively. All comparisons resulted in very high pass rates. More than 95{\%} of the TPS points were within 3{\%}/3 mm of both the gel measurement and MC simulation, both inside VOI50 and VOI90. Additionally, the repeated gel measurements showed excellent consistency, indicating reproducible delivery. Using MC simulations and gel measurements, this verification study successfully demonstrated that the RapidArc™ plan was both accurately calculated and delivered as planned.",
    author = "Sofie Ceberg and Isabel Gagne and Helen Gustafsson and Scherman, {Jonas Bengtsson} and Stine Korreman and Flemming Kj{\ae}r-Kristoffersen and Michelle Hilts and B{\"a}ck, {Sven {\AA}J}",
    year = "2010",
    month = "9",
    doi = "10.1088/0031-9155/55/17/001",
    language = "English",
    volume = "55",
    pages = "4885--4898",
    journal = "Physics in Medicine and Biology",
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    Ceberg, S, Gagne, I, Gustafsson, H, Scherman, JB, Korreman, S, Kjær-Kristoffersen, F, Hilts, M & Bäck, SÅJ 2010, 'RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation', Physics in Medicine and Biology, bind 55, nr. 17, s. 4885-4898. https://doi.org/10.1088/0031-9155/55/17/001

    RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation. / Ceberg, Sofie; Gagne, Isabel; Gustafsson, Helen; Scherman, Jonas Bengtsson; Korreman, Stine; Kjær-Kristoffersen, Flemming; Hilts, Michelle; Bäck, Sven ÅJ.

    I: Physics in Medicine and Biology, Bind 55, Nr. 17, 09.2010, s. 4885-4898.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation

    AU - Ceberg, Sofie

    AU - Gagne, Isabel

    AU - Gustafsson, Helen

    AU - Scherman, Jonas Bengtsson

    AU - Korreman, Stine

    AU - Kjær-Kristoffersen, Flemming

    AU - Hilts, Michelle

    AU - Bäck, Sven ÅJ

    PY - 2010/9

    Y1 - 2010/9

    N2 - The aim of this study was to verify the advanced inhomogeneous dose distribution produced by a volumetric arc therapy technique (RapidArc™) using 3D gel measurements and Monte Carlo (MC) simulations. The TPS (treatment planning system)-calculated dose distribution was compared with gel measurements and MC simulations, thus investigating any discrepancy between the planned dose delivery and the actual delivery. Additionally, the reproducibility of the delivery was investigated using repeated gel measurements. A prostate treatment plan was delivered to a 1.3 liter nPAG gel phantom using one single arc rotation and a target dose of 3.3 Gy. Magnetic resonance imaging of the gel was carried out using a 1.5 T scanner. The MC dose distributions were calculated using the VIMC-Arc code. The relative absorbed dose differences were calculated voxel-by-voxel, within the volume enclosed by the 90% isodose surface (VOI90), for the TPS versus gel and TPS versus MC. The differences between the verification methods, MC versus gel, and between two repeated gel measurements were investigated in the same way. For all volume comparisons, the mean value was within 1% and the standard deviation of the differences was within 2.5% (1SD). A 3D gamma analysis between the dose matrices were carried out using gamma criteria 3%/3 mm and 5%/5 mm (% dose difference and mm distance to agreement) within the volume enclosed by the 50% isodose surface (VOI50) and the 90% isodose surface (VOI90), respectively. All comparisons resulted in very high pass rates. More than 95% of the TPS points were within 3%/3 mm of both the gel measurement and MC simulation, both inside VOI50 and VOI90. Additionally, the repeated gel measurements showed excellent consistency, indicating reproducible delivery. Using MC simulations and gel measurements, this verification study successfully demonstrated that the RapidArc™ plan was both accurately calculated and delivered as planned.

    AB - The aim of this study was to verify the advanced inhomogeneous dose distribution produced by a volumetric arc therapy technique (RapidArc™) using 3D gel measurements and Monte Carlo (MC) simulations. The TPS (treatment planning system)-calculated dose distribution was compared with gel measurements and MC simulations, thus investigating any discrepancy between the planned dose delivery and the actual delivery. Additionally, the reproducibility of the delivery was investigated using repeated gel measurements. A prostate treatment plan was delivered to a 1.3 liter nPAG gel phantom using one single arc rotation and a target dose of 3.3 Gy. Magnetic resonance imaging of the gel was carried out using a 1.5 T scanner. The MC dose distributions were calculated using the VIMC-Arc code. The relative absorbed dose differences were calculated voxel-by-voxel, within the volume enclosed by the 90% isodose surface (VOI90), for the TPS versus gel and TPS versus MC. The differences between the verification methods, MC versus gel, and between two repeated gel measurements were investigated in the same way. For all volume comparisons, the mean value was within 1% and the standard deviation of the differences was within 2.5% (1SD). A 3D gamma analysis between the dose matrices were carried out using gamma criteria 3%/3 mm and 5%/5 mm (% dose difference and mm distance to agreement) within the volume enclosed by the 50% isodose surface (VOI50) and the 90% isodose surface (VOI90), respectively. All comparisons resulted in very high pass rates. More than 95% of the TPS points were within 3%/3 mm of both the gel measurement and MC simulation, both inside VOI50 and VOI90. Additionally, the repeated gel measurements showed excellent consistency, indicating reproducible delivery. Using MC simulations and gel measurements, this verification study successfully demonstrated that the RapidArc™ plan was both accurately calculated and delivered as planned.

    U2 - 10.1088/0031-9155/55/17/001

    DO - 10.1088/0031-9155/55/17/001

    M3 - Journal article

    VL - 55

    SP - 4885

    EP - 4898

    JO - Physics in Medicine and Biology

    JF - Physics in Medicine and Biology

    SN - 0031-9155

    IS - 17

    ER -

    Ceberg S, Gagne I, Gustafsson H, Scherman JB, Korreman S, Kjær-Kristoffersen F et al. RapidArc treatment verification in 3D using polymer gel dosimetry and Monte Carlo simulation. Physics in Medicine and Biology. 2010 sep;55(17):4885-4898. https://doi.org/10.1088/0031-9155/55/17/001