Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice:

Effects on liver DNA strand breaks in dams and offspring

Petra Jackson, Karin Sørig Hougaard, Anne Mette Zenner Boisen, Nicklas Raun Jacobsen, Keld Alstrup Jensen, Peter Møller, Gunnar Brunborg, Kristine Bjerve Gutzkow, Ole Andersen, Steffen Loft, Ulla Vogel, Erik Håkan Richard Wallin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m3 Printex 90 for 1 h/day on gestation days (GD) 8–18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 μg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3–5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring.
    OriginalsprogEngelsk
    TidsskriftNanotoxicology
    Vol/bind6
    Udgave nummer5
    Sider (fra-til)486-500
    ISSN1743-5390
    DOI
    StatusUdgivet - 2012

    Citer dette

    Jackson, P., Hougaard, K. S., Boisen, A. M. Z., Raun Jacobsen, N., Alstrup Jensen, K., Møller, P., ... Wallin, E. H. R. (2012). Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring. Nanotoxicology, 6(5), 486-500. https://doi.org/10.3109/17435390.2011.587902
    Jackson, Petra ; Hougaard, Karin Sørig ; Boisen, Anne Mette Zenner ; Raun Jacobsen, Nicklas ; Alstrup Jensen, Keld ; Møller, Peter ; Brunborg, Gunnar ; Gutzkow, Kristine Bjerve ; Andersen, Ole ; Loft, Steffen ; Vogel, Ulla ; Wallin, Erik Håkan Richard. / Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring. I: Nanotoxicology. 2012 ; Bind 6, Nr. 5. s. 486-500.
    @article{a85bb11b2d5146cf9f2d1861c3726877,
    title = "Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice:: Effects on liver DNA strand breaks in dams and offspring",
    abstract = "Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m3 Printex 90 for 1 h/day on gestation days (GD) 8–18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 μg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3–5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring.",
    author = "Petra Jackson and Hougaard, {Karin S{\o}rig} and Boisen, {Anne Mette Zenner} and {Raun Jacobsen}, Nicklas and {Alstrup Jensen}, Keld and Peter M{\o}ller and Gunnar Brunborg and Gutzkow, {Kristine Bjerve} and Ole Andersen and Steffen Loft and Ulla Vogel and Wallin, {Erik H{\aa}kan Richard}",
    year = "2012",
    doi = "10.3109/17435390.2011.587902",
    language = "English",
    volume = "6",
    pages = "486--500",
    journal = "Nanotoxicology",
    issn = "1743-5390",
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    Jackson, P, Hougaard, KS, Boisen, AMZ, Raun Jacobsen, N, Alstrup Jensen, K, Møller, P, Brunborg, G, Gutzkow, KB, Andersen, O, Loft, S, Vogel, U & Wallin, EHR 2012, 'Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring', Nanotoxicology, bind 6, nr. 5, s. 486-500. https://doi.org/10.3109/17435390.2011.587902

    Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring. / Jackson, Petra; Hougaard, Karin Sørig; Boisen, Anne Mette Zenner; Raun Jacobsen, Nicklas; Alstrup Jensen, Keld ; Møller, Peter; Brunborg, Gunnar; Gutzkow, Kristine Bjerve; Andersen, Ole; Loft, Steffen; Vogel, Ulla; Wallin, Erik Håkan Richard.

    I: Nanotoxicology, Bind 6, Nr. 5, 2012, s. 486-500.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice:

    T2 - Effects on liver DNA strand breaks in dams and offspring

    AU - Jackson, Petra

    AU - Hougaard, Karin Sørig

    AU - Boisen, Anne Mette Zenner

    AU - Raun Jacobsen, Nicklas

    AU - Alstrup Jensen, Keld

    AU - Møller, Peter

    AU - Brunborg, Gunnar

    AU - Gutzkow, Kristine Bjerve

    AU - Andersen, Ole

    AU - Loft, Steffen

    AU - Vogel, Ulla

    AU - Wallin, Erik Håkan Richard

    PY - 2012

    Y1 - 2012

    N2 - Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m3 Printex 90 for 1 h/day on gestation days (GD) 8–18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 μg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3–5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring.

    AB - Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m3 Printex 90 for 1 h/day on gestation days (GD) 8–18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 μg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3–5 days after exposure, and at weaning. Levels of DNA strand breaks were assessed in maternal BAL cells and liver, and in offspring liver. Persistent lung inflammation was observed in exposed mothers. Inhalation exposure induced more DNA strand breaks in the liver of mothers and their offspring, whereas intratracheal instillation did not. Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring.

    U2 - 10.3109/17435390.2011.587902

    DO - 10.3109/17435390.2011.587902

    M3 - Journal article

    VL - 6

    SP - 486

    EP - 500

    JO - Nanotoxicology

    JF - Nanotoxicology

    SN - 1743-5390

    IS - 5

    ER -