Prenatal Exposure to Carbon Black (Printex 90): Effects on Sexual Development and Neurofunction

Petra Jackson, Ulla Vogel, Håkan Wallin, Karin Sørig Hougaard

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    Maternal pulmonary exposure to ultrafine particles during pregnancy may affect the health of the child. Developmental toxicity of carbon black (Printex 90) nanoparticles was evaluated in a mouse model. Time-mated mice were intratracheally instilled with Printex 90 dispersed in Millipore water on gestation days (GD) 7, 10, 15 and 18, with total doses of 11, 54 and 268 mu g Printex 90/animal. The female offspring prenatally exposed to 268 mu g Printex 90/animal displayed altered habituation pattern during the Open field test.
    TidsskriftBasic & Clinical Pharmacology & Toxicology
    Udgave nummer6
    Sider (fra-til)434-437
    StatusUdgivet - 2011

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