Platinum(II) complexes block the entry of T4 phage DNA into the host cells

Gustaw Kerszman; Jens Josephsen; Bo  Fernholm

doi:10.1016/0009-2797(79)90166-2

Platinum(II) complexes block the entry of T4 phage DNA into the host cells

Gustaw Kerszman, Jens Josephsen, Bo Fernholm

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.

Originalsprog	Engelsk
Tidsskrift	Chemico-Biological Interactions
Vol/bind	28
Udgave nummer	2-3
Sider (fra-til)	259-268
Antal sider	10
ISSN	0009-2797
DOI	https://doi.org/10.1016/0009-2797(79)90166-2
Status	Udgivet - 1979

Link til dokument

10.1016/0009-2797(79)90166-2

Citer dette

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title = "Platinum(II) complexes block the entry of T4 phage DNA into the host cells",

abstract = "The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.",

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AU - Josephsen, Jens

AU - Fernholm , Bo

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N2 - The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.

AB - The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.

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DO - 10.1016/0009-2797(79)90166-2

M3 - Journal article

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