Perturbing the activity of the superior temporal gyrus during pain encoding prevents the exaggeration of pain memories: A virtual lesion study using single-pulse transcranial magnetic stimulation

Francis Houde, Marylie Martel, Alexia Coulombe-Lévêque, Marie Philippe Harvey, Vincent Auclair, David Mathieu, Kevin Whittingstall, Philippe Goffaux, Guillaume Léonard*

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Abstract

Background: Past studies have shown that pain memories are often inaccurate, a phenomenon known as mnemonic pain bias. Pain memories are thought to play an important role on how future pain is felt. Recent evidence from our laboratory suggests that individuals who exaggerate past pain display increased superior temporal gyrus (STG) activity during the encoding of experimental painful stimulations, suggesting that this brain structure plays an important role in pain memories. Objective: /hypothesis. To determine whether a virtual lesion paradigm, targeting the STG during pain encoding, can affect long-lasting pain memories. We hypothesized that interfering with the activity of the STG would attenuate mnemonic bias. Methods: Randomized double-blind study with two parallel groups. Participants received either sham (n = 21) or real (n = 21) transcranial magnetic stimulation (TMS - virtual lesion paradigm) over the STG during pain encoding (milliseconds after the administration of a painful stimuli). Pain intensity and unpleasantness were evaluated using a visual analog scale (VAS; 0 to 10) immediately after the painful event, and at recall, 2 months later. The mnemonic pain bias (calculated by subtracting the pain scores obtained at recall from the pain score obtained during encoding) was compared between the two groups for both pain intensity and unpleasantness. Results: Participants in both groups did not differ in terms of age and gender (real TMS = 27 years ± 9, 43% female; sham TMS = 25 years ± 4, 49% female; p > 0.64). The mnemonic bias related to pain intensity was similar in both groups (p = 0.83). However, the mnemonic bias related to pain unpleasantness was lower in the real TMS group (p = 0.04). Conclusions: Our results provide the first evidence that the STG, is causally involved in the formation of biased memories of pain unpleasantness.
OriginalsprogEngelsk
Artikelnummer107174
TidsskriftNeurobiology of Learning and Memory
Vol/bind169
ISSN1074-7427
DOI
StatusUdgivet - mar. 2020
Udgivet eksterntJa

Emneord

  • Memory
  • Pain
  • Parahippocampal gyrus
  • Superior temporal gyrus
  • Transcranial magnetic stimulation
  • Virtual lesion

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