Pandemic versus Epidemic Influenza Mortality: A Pattern of Changing Age Distribution

Lone Simonsen, Matthew J. Clarke, Lawrence B. Schonberger, Nancy H. Arden, Nancy J. Cox, Keiji Fukuda

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Resumé

Almost all deaths related to current influenza epidemics occur among the elderly. However, mortality was greatest among the young during the 1918-1919 pandemic. This study compared the age distribution of influenza-related deaths in the United States during this century's three influenza A pandemics with that of the following epidemics. Half of influenza-related deaths during the 1968- 1969 influenza A (H3N2) pandemic and large proportions of influenza-related deaths during the 1957-1958 influenza A (H2N2) and the 1918-1919 influenza A (H1N1) pandemics occurred among persons <65 years old. However, this group accounted for decrementally smaller proportions of deaths during the first decade following each pandemic. A model suggested that this mortality pattern may be explained by selective acquisition of protection against fatal illness among younger persons. The large proportion of influenza-related deaths during each pandemic and the following decade among persons <65 years old should be considered in planning for pandemics.
OriginalsprogEngelsk
TidsskriftJournal of Infectious Diseases
Vol/bind178
Udgave nummer1
Antal sider8
ISSN0022-1899
StatusUdgivet - 1998
Udgivet eksterntJa

Citer dette

Simonsen, L., Clarke, M. J., Schonberger, L. B., Arden, N. H., Cox, N. J., & Fukuda, K. (1998). Pandemic versus Epidemic Influenza Mortality: A Pattern of Changing Age Distribution. Journal of Infectious Diseases, 178(1).
Simonsen, Lone ; Clarke, Matthew J. ; Schonberger, Lawrence B. ; Arden, Nancy H. ; Cox, Nancy J. ; Fukuda, Keiji. / Pandemic versus Epidemic Influenza Mortality : A Pattern of Changing Age Distribution. I: Journal of Infectious Diseases. 1998 ; Bind 178, Nr. 1.
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abstract = "Almost all deaths related to current influenza epidemics occur among the elderly. However, mortality was greatest among the young during the 1918-1919 pandemic. This study compared the age distribution of influenza-related deaths in the United States during this century's three influenza A pandemics with that of the following epidemics. Half of influenza-related deaths during the 1968- 1969 influenza A (H3N2) pandemic and large proportions of influenza-related deaths during the 1957-1958 influenza A (H2N2) and the 1918-1919 influenza A (H1N1) pandemics occurred among persons <65 years old. However, this group accounted for decrementally smaller proportions of deaths during the first decade following each pandemic. A model suggested that this mortality pattern may be explained by selective acquisition of protection against fatal illness among younger persons. The large proportion of influenza-related deaths during each pandemic and the following decade among persons <65 years old should be considered in planning for pandemics.",
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Simonsen, L, Clarke, MJ, Schonberger, LB, Arden, NH, Cox, NJ & Fukuda, K 1998, 'Pandemic versus Epidemic Influenza Mortality: A Pattern of Changing Age Distribution' Journal of Infectious Diseases, bind 178, nr. 1.

Pandemic versus Epidemic Influenza Mortality : A Pattern of Changing Age Distribution. / Simonsen, Lone; Clarke, Matthew J.; Schonberger, Lawrence B.; Arden, Nancy H.; Cox, Nancy J.; Fukuda, Keiji.

I: Journal of Infectious Diseases, Bind 178, Nr. 1, 1998.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Pandemic versus Epidemic Influenza Mortality

T2 - A Pattern of Changing Age Distribution

AU - Simonsen, Lone

AU - Clarke, Matthew J.

AU - Schonberger, Lawrence B.

AU - Arden, Nancy H.

AU - Cox, Nancy J.

AU - Fukuda, Keiji

PY - 1998

Y1 - 1998

N2 - Almost all deaths related to current influenza epidemics occur among the elderly. However, mortality was greatest among the young during the 1918-1919 pandemic. This study compared the age distribution of influenza-related deaths in the United States during this century's three influenza A pandemics with that of the following epidemics. Half of influenza-related deaths during the 1968- 1969 influenza A (H3N2) pandemic and large proportions of influenza-related deaths during the 1957-1958 influenza A (H2N2) and the 1918-1919 influenza A (H1N1) pandemics occurred among persons <65 years old. However, this group accounted for decrementally smaller proportions of deaths during the first decade following each pandemic. A model suggested that this mortality pattern may be explained by selective acquisition of protection against fatal illness among younger persons. The large proportion of influenza-related deaths during each pandemic and the following decade among persons <65 years old should be considered in planning for pandemics.

AB - Almost all deaths related to current influenza epidemics occur among the elderly. However, mortality was greatest among the young during the 1918-1919 pandemic. This study compared the age distribution of influenza-related deaths in the United States during this century's three influenza A pandemics with that of the following epidemics. Half of influenza-related deaths during the 1968- 1969 influenza A (H3N2) pandemic and large proportions of influenza-related deaths during the 1957-1958 influenza A (H2N2) and the 1918-1919 influenza A (H1N1) pandemics occurred among persons <65 years old. However, this group accounted for decrementally smaller proportions of deaths during the first decade following each pandemic. A model suggested that this mortality pattern may be explained by selective acquisition of protection against fatal illness among younger persons. The large proportion of influenza-related deaths during each pandemic and the following decade among persons <65 years old should be considered in planning for pandemics.

M3 - Journal article

VL - 178

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

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ER -