P40-F The relationship between age and SICI parameters obtained with threshold tracking TMS

Publikation: KonferencebidragPosterForskningpeer review

Abstract

Background
Recently developed threshold tracking TMS (TT-TMS) paired pulse techniques have been shown to be of benefit in clinical diagnostic practice. Reduced Short Interval Cortical Inhibition (SICI) with increasing age has been shown in several studies using conventional paired-pulse TMS techniques. However, TT-TMS SICI parameters did not correlate to age in healthy subjects in a previous study (Shibuya et al., 2016). We aimed in this study to present the preliminary results of our normal material on TT-SICI and the relationship between SICI measurements and age.

Material and methods
Thirty-three healthy subjects (mean age: 51.06 ± 2.48, range: 23–77) were included. Paired-pulse TT-TMS was undertaken using a 90 mm figure-of-eight coil applied to the motor cortex, with currents generated by BiStim system controlled by Qtrac software. The motor evoked potential (MEP) response was recorded over the first dorsal interosseus (FDI). MEP amplitude was set to a target value of 0.2 mV, and the changes in the intensity of the test stimulus required to generate this target MEP were measured. The relationship between age and SICI measurements were analyzed using regression analysis.

Results
Resting motor threshold (RMT) (MSO, %) (mean: 54.43 ± 2.41) and SICI (%) at 1 ms (12.01 ± 1.86), 2.5 ms (11.02 ± 1.65), 3 ms (8.20 ± 1.69) and 1–7 ms (5.93 ± 1.12) on TT-TMS were analysed. RMT increased with increasing age (r = 0.45, p = 0.08), while age had an inverse relationship with SICI on 1 ms (r = −0.49, p = 0.003), 2.5 ms (r = −0.45, p = 0.008), 3 ms (r = −0.41, p = 0.019) and 1–7 ms (r = −0.41, p = 0.017).

Conclusions
SICI parameters closely relate to age for TT-TMS similar to previously reported conventional. Further studies are required with large groups of healthy subjects.
OriginalsprogEngelsk
Publikationsdatojul. 2019
Antal sider1
StatusUdgivet - jul. 2019
Udgivet eksterntJa
Begivenhed17th European Congress of Clinical Neurophysiology - Warszawa, Polen
Varighed: 5 jun. 20218 jun. 2021

Konference

Konference17th European Congress of Clinical Neurophysiology
Land/OmrådePolen
ByWarszawa
Periode05/06/202108/06/2021

Citer dette