p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate

Pia Nyeng, Silja Heilmann, Zarah Maria Löf Öhlin, Nina Fransén Pettersson, Florian Malte Hermann, Albert B. Reynolds, Henrik Semb

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate.
OriginalsprogEngelsk
TidsskriftDevelopmental Cell
Vol/bind49
Udgave nummer1
Sider (fra-til)31-47
Antal sider17
ISSN1534-5807
DOI
StatusUdgivet - 2019
Udgivet eksterntJa

Citer dette

Nyeng, P., Heilmann, S., Öhlin, Z. M. L., Pettersson, N. F., Hermann, F. M., Reynolds, A. B., & Semb, H. (2019). p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. Developmental Cell, 49(1), 31-47. https://doi.org/10.1016/j.devcel.2019.02.005
Nyeng, Pia ; Heilmann, Silja ; Öhlin, Zarah Maria Löf ; Pettersson, Nina Fransén ; Hermann, Florian Malte ; Reynolds, Albert B. ; Semb, Henrik . / p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. I: Developmental Cell. 2019 ; Bind 49, Nr. 1. s. 31-47.
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abstract = "The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate.",
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Nyeng, P, Heilmann, S, Öhlin, ZML, Pettersson, NF, Hermann, FM, Reynolds, AB & Semb, H 2019, 'p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate' Developmental Cell, bind 49, nr. 1, s. 31-47. https://doi.org/10.1016/j.devcel.2019.02.005

p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. / Nyeng, Pia; Heilmann, Silja; Öhlin, Zarah Maria Löf; Pettersson, Nina Fransén; Hermann, Florian Malte; Reynolds, Albert B.; Semb, Henrik .

I: Developmental Cell, Bind 49, Nr. 1, 2019, s. 31-47.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate

AU - Nyeng, Pia

AU - Heilmann, Silja

AU - Öhlin, Zarah Maria Löf

AU - Pettersson, Nina Fransén

AU - Hermann, Florian Malte

AU - Reynolds, Albert B.

AU - Semb, Henrik

PY - 2019

Y1 - 2019

N2 - The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate.

AB - The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate.

U2 - 10.1016/j.devcel.2019.02.005

DO - 10.1016/j.devcel.2019.02.005

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JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

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