Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014–15

Michaela Tinggaard*, Hans Christian Slotved, Kurt Fuursted, Maiken Worsøe Rosenstierne, Gitte Kronborg, Anne Mette Lebech, Kristina Thorsteinsson, Terese L. Katzenstein, Merete Storgaard, Inge Kristine Holden, Isik Somuncu Johansen, Thomas Benfield

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Abstract

Introduction: Outbreaks of invasive meningococcal disease (IMD) among men who have sex with men (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C have been described. We aimed to determine the oral and anal carriage rates and genogroups of Nm among MSM living with HIV. Methods: Sexually active MSM living with HIV were included. A questionnaire, an oral wash sample and an anal swab were collected at baseline and 12 months follow-up. Identification of Nm and genogrouping was performed using real-time polymerase chain reaction analysis. Results: Among 82 MSM, the Nm carriage rate was 31.7% (95% CI 21.9–42.9) at baseline. The oral carriage rate was 24.4% (95% CI 15.6–35.1) and the anal rate was 11.0% (95% CI 5.1–19.8). Non-groupable Nm were most prevalent followed by genogroup B and genogroup Y. Rates were similar at follow-up. Conclusion: Strains of Nm were detected in both oral washes and anal samples in our study. Our results suggest that Nm may be transmitted sexually among MSM. Non-groupable Nm were predominant in our population and no genogroup C Nm were detected.

OriginalsprogEngelsk
TidsskriftInternational Journal of Infectious Diseases
Vol/bind105
Sider (fra-til)337-344
Antal sider8
ISSN1201-9712
DOI
StatusUdgivet - apr. 2021
Udgivet eksterntJa

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