Occupational noise exposure and risk of incident stroke: a pooled study of five Scandinavian cohorts

Jesse D. Thacher*, Nina Roswall, Claudia Lissåker, Gunn Marit Aasvang, Maria Albin, Eva M. Andersson, Gunnar Engström, Charlotta Eriksson, Ulla Arthur Hvidtfeldt, Matthias Ketzel, Jibran Khan, Timo Lanki, Petter L.S. Ljungman, Kristoffer Mattisson, Peter Molnar, Ole Raaschou-Nielsen, Anna Oudin, Kim Overvad, Sesilje Bondo Petersen, Göran PershagenAslak Harbo Poulsen, Andrei Pyko, Debora Rizzuto, Annika Rosengren, Linus Schioler, Mattias Sjöström, Leo Stockfelt, Pekka Tiittanen, Gerd Sallsten, Mikael Ögren, Jenny Selander, Mette Sorensen

*Corresponding author

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Objectives: To investigate the association between occupational noise exposure and stroke incidence in a pooled study of five Scandinavian cohorts (NordSOUND). Methods: We pooled and harmonised data from five Scandinavian cohorts resulting in 78 389 participants. We obtained job data from national registries or questionnaires and recoded these to match a job-exposure matrix developed in Sweden, which specified the annual average daily noise exposure in five exposure classes (LAeq8h): <70, 70-74, 75-79, 80-84, ≥85 dB(A). We identified residential address history and estimated 1-year average road traffic noise at baseline. Using national patient and mortality registers, we identified 7777 stroke cases with a median follow-up of 20.2 years. Analyses were conducted using Cox proportional hazards models adjusting for individual and area-level potential confounders. Results: Exposure to occupational noise at baseline was not associated with overall stroke in the fully adjusted models. For ischaemic stroke, occupational noise was associated with HRs (95% CI) of 1.08 (0.98 to 1.20), 1.09 (0.97 to 1.24) and 1.06 (0.92 to 1.21) in the 75-79, 80-84 and ≥85 dB(A) exposure groups, compared with <70 dB(A), respectively. In subanalyses using time-varying occupational noise exposure, we observed an indication of higher stroke risk among the most exposed (≥85 dB(A)), particularly when restricting analyses to people exposed to occupational noise within the last year (HR: 1.27; 95% CI: 0.99 to 1.63). Conclusions: We found no association between occupational noise and risk of overall stroke after adjustment for confounders. However, the non-significantly increased risk of ischaemic stroke warrants further investigation.

TidsskriftOccupational and Environmental Medicine
Udgave nummer9
Sider (fra-til)594-601
Antal sider8
StatusUdgivet - 1 sep. 2022


  • epidemiology
  • noise
  • public health

Citer dette