Nye molekylære markører ved de kroniske myeloproliferative sygdomme: I. Polycythaemia rubra vera-1-genet

Thomas Stauffer Larsen*, Niels Pallisgaard, Jacob Haaber Christensen, Paul Gram-Hansen, Gitte B. Kerndrup, Michael Boe Møller, Hans Carl Hasselbalch

*Corresponding author

Publikation: Bidrag til tidsskriftReviewpeer review

Abstract

PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having "masked" PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.

Bidragets oversatte titelNew molecular markers within the chronic myeloproliferative disorders. I: The PRV-1 gene
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind168
Udgave nummer39
Sider (fra-til)3295-3299
Antal sider5
ISSN0041-5782
StatusUdgivet - 25 sep. 2006
Udgivet eksterntJa

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