Non-Viral Deoxyribonucleoside Kinases: Diversity and Practical Use

Louise Slot Christiansen, Birgitte Munch-Petersen, Wolfgang Knecht

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.
OriginalsprogEngelsk
TidsskriftJournal of Genetics and Genomics
Vol/bind42
Udgave nummer5
Sider (fra-til)235-248
Antal sider14
ISSN1673-8527
DOI
StatusUdgivet - 20 maj 2015

Emneord

  • Deoxynucleoside kinases
  • Deoxynucleosides
  • Deoxynucleotides
  • Evolution
  • Nucleoside salvage pathway
  • Suicide gene therapy

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