Non-Viral Deoxyribonucleoside Kinases

Diversity and Practical Use

Louise Slot Christiansen, Birgitte Munch-Petersen, Wolfgang Knecht

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Resumé

Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.
OriginalsprogEngelsk
TidsskriftJournal of Genetics and Genomics
Vol/bind42
Udgave nummer5
Sider (fra-til)235-248
Antal sider14
ISSN1673-8527
DOI
StatusUdgivet - 20 maj 2015

Emneord

  • Deoxynucleoside kinases
  • Deoxynucleosides
  • Deoxynucleotides
  • Evolution
  • Nucleoside salvage pathway
  • Suicide gene therapy

Citer dette

Christiansen, Louise Slot ; Munch-Petersen, Birgitte ; Knecht, Wolfgang. / Non-Viral Deoxyribonucleoside Kinases : Diversity and Practical Use. I: Journal of Genetics and Genomics. 2015 ; Bind 42, Nr. 5. s. 235-248.
@article{dca2a3a011cd4604b9941bf4725cab7c,
title = "Non-Viral Deoxyribonucleoside Kinases: Diversity and Practical Use",
abstract = "Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.",
keywords = "Deoxynucleoside kinases, Deoxynucleosides, Deoxynucleotides, Evolution, Nucleoside salvage pathway, Suicide gene therapy",
author = "Christiansen, {Louise Slot} and Birgitte Munch-Petersen and Wolfgang Knecht",
year = "2015",
month = "5",
day = "20",
doi = "10.1016/j.jgg.2015.01.003",
language = "English",
volume = "42",
pages = "235--248",
journal = "Journal of Genetics and Genomics",
issn = "1673-8527",
publisher = "Elsevier BV",
number = "5",

}

Christiansen, LS, Munch-Petersen, B & Knecht, W 2015, 'Non-Viral Deoxyribonucleoside Kinases: Diversity and Practical Use', Journal of Genetics and Genomics, bind 42, nr. 5, s. 235-248. https://doi.org/10.1016/j.jgg.2015.01.003

Non-Viral Deoxyribonucleoside Kinases : Diversity and Practical Use. / Christiansen, Louise Slot; Munch-Petersen, Birgitte; Knecht, Wolfgang.

I: Journal of Genetics and Genomics, Bind 42, Nr. 5, 20.05.2015, s. 235-248.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Non-Viral Deoxyribonucleoside Kinases

T2 - Diversity and Practical Use

AU - Christiansen, Louise Slot

AU - Munch-Petersen, Birgitte

AU - Knecht, Wolfgang

PY - 2015/5/20

Y1 - 2015/5/20

N2 - Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.

AB - Deoxyribonucleoside kinases (dNKs) phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds. dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non-mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.

KW - Deoxynucleoside kinases

KW - Deoxynucleosides

KW - Deoxynucleotides

KW - Evolution

KW - Nucleoside salvage pathway

KW - Suicide gene therapy

U2 - 10.1016/j.jgg.2015.01.003

DO - 10.1016/j.jgg.2015.01.003

M3 - Journal article

VL - 42

SP - 235

EP - 248

JO - Journal of Genetics and Genomics

JF - Journal of Genetics and Genomics

SN - 1673-8527

IS - 5

ER -

Christiansen LS, Munch-Petersen B, Knecht W. Non-Viral Deoxyribonucleoside Kinases: Diversity and Practical Use. Journal of Genetics and Genomics. 2015 maj 20;42(5):235-248. https://doi.org/10.1016/j.jgg.2015.01.003

Link til dokument