Non-Coding RNA in Pancreas and β-Cell Development

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. The role of long non-coding RNAs (lncRNA) in islet and β-cells is less investigated than for miRNAs, but knowledge is increasing rapidly. The advent of ultra-deep RNA sequencing has enabled the identification of highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their roles in islet cells are currently only characterized for a few of these lncRNAs, and these are often associated with β-cell super-enhancers and regulate neighboring gene activity. Moreover, ncRNAs present in imprinted regions are involved in pancreas development and β-cell function. Altogether, these observations support significant and important actions of ncRNAs in β-cell development and function.
OriginalsprogEngelsk
Artikelnummer41
TidsskriftNon-Coding R N A
Vol/bind4
Udgave nummer4
Antal sider25
ISSN2311-553X
DOI
StatusUdgivet - 2018

Citer dette

@article{5bf4ec50888149a0a743eea502bfd838,
title = "Non-Coding RNA in Pancreas and β-Cell Development",
abstract = "In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. The role of long non-coding RNAs (lncRNA) in islet and β-cells is less investigated than for miRNAs, but knowledge is increasing rapidly. The advent of ultra-deep RNA sequencing has enabled the identification of highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their roles in islet cells are currently only characterized for a few of these lncRNAs, and these are often associated with β-cell super-enhancers and regulate neighboring gene activity. Moreover, ncRNAs present in imprinted regions are involved in pancreas development and β-cell function. Altogether, these observations support significant and important actions of ncRNAs in β-cell development and function.",
keywords = "non-coding RNAs, long non-coding RNAs, long intergenic non-coding RNAs, microRNA, small nucleolar RNAs, piwi associated RNAs, circular RNAs, β-cell, α-cell, islets of Langerhans, pancreas, fetal development",
author = "Wong, {Wilson W.K.} and S{\o}rensen, {Anja Elaine} and Mugdha Joglekar and Hardikar, {Anandwardhan Awadhoot} and Dalgaard, {Louise Torp}",
year = "2018",
doi = "10.3390/ncrna4040041",
language = "English",
volume = "4",
journal = "Non-Coding R N A",
issn = "2311-553X",
publisher = "M D P I AG",
number = "4",

}

Non-Coding RNA in Pancreas and β-Cell Development. / Wong, Wilson W.K.; Sørensen, Anja Elaine; Joglekar, Mugdha; Hardikar, Anandwardhan Awadhoot; Dalgaard, Louise Torp.

I: Non-Coding R N A, Bind 4, Nr. 4, 41, 2018.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Non-Coding RNA in Pancreas and β-Cell Development

AU - Wong, Wilson W.K.

AU - Sørensen, Anja Elaine

AU - Joglekar, Mugdha

AU - Hardikar, Anandwardhan Awadhoot

AU - Dalgaard, Louise Torp

PY - 2018

Y1 - 2018

N2 - In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. The role of long non-coding RNAs (lncRNA) in islet and β-cells is less investigated than for miRNAs, but knowledge is increasing rapidly. The advent of ultra-deep RNA sequencing has enabled the identification of highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their roles in islet cells are currently only characterized for a few of these lncRNAs, and these are often associated with β-cell super-enhancers and regulate neighboring gene activity. Moreover, ncRNAs present in imprinted regions are involved in pancreas development and β-cell function. Altogether, these observations support significant and important actions of ncRNAs in β-cell development and function.

AB - In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. The role of long non-coding RNAs (lncRNA) in islet and β-cells is less investigated than for miRNAs, but knowledge is increasing rapidly. The advent of ultra-deep RNA sequencing has enabled the identification of highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their roles in islet cells are currently only characterized for a few of these lncRNAs, and these are often associated with β-cell super-enhancers and regulate neighboring gene activity. Moreover, ncRNAs present in imprinted regions are involved in pancreas development and β-cell function. Altogether, these observations support significant and important actions of ncRNAs in β-cell development and function.

KW - non-coding RNAs

KW - long non-coding RNAs

KW - long intergenic non-coding RNAs

KW - microRNA

KW - small nucleolar RNAs

KW - piwi associated RNAs

KW - circular RNAs

KW - β-cell

KW - α-cell

KW - islets of Langerhans

KW - pancreas

KW - fetal development

U2 - 10.3390/ncrna4040041

DO - 10.3390/ncrna4040041

M3 - Review

VL - 4

JO - Non-Coding R N A

JF - Non-Coding R N A

SN - 2311-553X

IS - 4

M1 - 41

ER -