Resumé
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 41 |
| Tidsskrift | Non-Coding R N A |
| Vol/bind | 4 |
| Udgave nummer | 4 |
| Antal sider | 25 |
| ISSN | 2311-553X |
| DOI | |
| Status | Udgivet - 2018 |
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Non-Coding RNA in Pancreas and β-Cell Development. / Wong, Wilson W.K.; Sørensen, Anja Elaine; Joglekar, Mugdha; Hardikar, Anandwardhan Awadhoot; Dalgaard, Louise Torp.
I: Non-Coding R N A, Bind 4, Nr. 4, 41, 2018.Publikation: Bidrag til tidsskrift › Review › Forskning › peer review
TY - JOUR
T1 - Non-Coding RNA in Pancreas and β-Cell Development
AU - Wong, Wilson W.K.
AU - Sørensen, Anja Elaine
AU - Joglekar, Mugdha
AU - Hardikar, Anandwardhan Awadhoot
AU - Dalgaard, Louise Torp
PY - 2018
Y1 - 2018
N2 - In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. The role of long non-coding RNAs (lncRNA) in islet and β-cells is less investigated than for miRNAs, but knowledge is increasing rapidly. The advent of ultra-deep RNA sequencing has enabled the identification of highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their roles in islet cells are currently only characterized for a few of these lncRNAs, and these are often associated with β-cell super-enhancers and regulate neighboring gene activity. Moreover, ncRNAs present in imprinted regions are involved in pancreas development and β-cell function. Altogether, these observations support significant and important actions of ncRNAs in β-cell development and function.
AB - In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. The role of long non-coding RNAs (lncRNA) in islet and β-cells is less investigated than for miRNAs, but knowledge is increasing rapidly. The advent of ultra-deep RNA sequencing has enabled the identification of highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their roles in islet cells are currently only characterized for a few of these lncRNAs, and these are often associated with β-cell super-enhancers and regulate neighboring gene activity. Moreover, ncRNAs present in imprinted regions are involved in pancreas development and β-cell function. Altogether, these observations support significant and important actions of ncRNAs in β-cell development and function.
KW - non-coding RNAs
KW - long non-coding RNAs
KW - long intergenic non-coding RNAs
KW - microRNA
KW - small nucleolar RNAs
KW - piwi associated RNAs
KW - circular RNAs
KW - β-cell
KW - α-cell
KW - islets of Langerhans
KW - pancreas
KW - fetal development
U2 - 10.3390/ncrna4040041
DO - 10.3390/ncrna4040041
M3 - Review
VL - 4
JO - Non-Coding R N A
JF - Non-Coding R N A
SN - 2311-553X
IS - 4
M1 - 41
ER -