No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma

Nina Roswall, Mette Sørensen, Elvira Vaclavik Bräuner, Anne Tjønneland, Ole Raaschou-Nielsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.

Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.

Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.

Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.

Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224–6. ©2017 AACR.
OriginalsprogEngelsk
TidsskriftCancer Epidemiology, Biomarkers & Prevention
Vol/bind27
Udgave nummer2
Sider (fra-til)224-226
ISSN1055-9965
DOI
StatusUdgivet - 2018

Bibliografisk note

This article has been found as a ’Free Version’ from the Publisher on June 7 2019. When access to the article closes, please notify rucforsk@ruc.dk

Citer dette

Roswall, Nina ; Sørensen, Mette ; Bräuner, Elvira Vaclavik ; Tjønneland, Anne ; Raaschou-Nielsen, Ole. / No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma. I: Cancer Epidemiology, Biomarkers & Prevention. 2018 ; Bind 27, Nr. 2. s. 224-226.
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title = "No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma",
abstract = "Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224–6. {\circledC}2017 AACR.",
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No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma. / Roswall, Nina; Sørensen, Mette; Bräuner, Elvira Vaclavik; Tjønneland, Anne; Raaschou-Nielsen, Ole.

I: Cancer Epidemiology, Biomarkers & Prevention, Bind 27, Nr. 2, 2018, s. 224-226.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - No Association between Organochlorine Concentrations in Adipose Tissue and Survival after Non-Hodgkin Lymphoma

AU - Roswall, Nina

AU - Sørensen, Mette

AU - Bräuner, Elvira Vaclavik

AU - Tjønneland, Anne

AU - Raaschou-Nielsen, Ole

N1 - This article has been found as a ’Free Version’ from the Publisher on June 7 2019. When access to the article closes, please notify rucforsk@ruc.dk

PY - 2018

Y1 - 2018

N2 - Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224–6. ©2017 AACR.

AB - Background: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy in the world. Involvement of organochlorines has been proposed in disease etiology. No study has investigated organochlorine exposure in relation to survival after a NHL diagnosis.Methods: In a survivor cohort consisting of 232 NHL cases from the Danish Diet, Cancer and Health cohort, we examined the association between adipose tissue organochlorine concentrations [polychlorinated biphenyls (PCBs) and pesticides] and subsequent survival, using Cox proportional hazards models.Results: We found no statistically significant association between organochlorine concentrations and subsequent survival. If anything, there was a nonsignificant tendency toward an inverse association with PCBs, but not pesticides.Conclusions: In conclusion, the current study does not support an increased risk of death among NHL patients with high tissue concentrations of organochlorines.Impact: This is the first study to investigate adipose organochlorine concentrations and survival after a NHL diagnosis. Cancer Epidemiol Biomarkers Prev; 27(2); 224–6. ©2017 AACR.

UR - http://cebp.aacrjournals.org/content/27/2/224

U2 - 10.1158/1055-9965.EPI-17-0937

DO - 10.1158/1055-9965.EPI-17-0937

M3 - Journal article

VL - 27

SP - 224

EP - 226

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 2

ER -